Difference between revisions of "Small cell carcinoma"

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(+paraneoplastic)
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*Breast.<ref name=pmid21657157>{{Cite journal  | last1 = Cesaretti | first1 = M. | last2 = Guarnieri | first2 = A. | last3 = Gaggelli | first3 = I. | last4 = Tirone | first4 = A. | last5 = Francioli | first5 = N. | last6 = Carli | first6 = AF. | title = Small cell carcinoma of the breast. Report of a case. | journal = Ann Ital Chir | volume = 82 | issue = 1 | pages = 61-4 | month =  | year =  | doi =  | PMID = 21657157 }}</ref>
*Breast.<ref name=pmid21657157>{{Cite journal  | last1 = Cesaretti | first1 = M. | last2 = Guarnieri | first2 = A. | last3 = Gaggelli | first3 = I. | last4 = Tirone | first4 = A. | last5 = Francioli | first5 = N. | last6 = Carli | first6 = AF. | title = Small cell carcinoma of the breast. Report of a case. | journal = Ann Ital Chir | volume = 82 | issue = 1 | pages = 61-4 | month =  | year =  | doi =  | PMID = 21657157 }}</ref>
*Thyroid gland.<ref name=pmid21644012>{{Cite journal  | last1 = Beach | first1 = DF. | last2 = Klump | first2 = WJ. | last3 = Haddad | first3 = G. | last4 = Reid | first4 = LM. | last5 = Schwarting | first5 = R. | last6 = Hageboutros | first6 = A. | title = Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. | journal = Med Oncol | volume =  | issue =  | pages =  | month = Jun | year = 2011 | doi = 10.1007/s12032-011-9996-7 | PMID = 21644012 }}</ref>
*Thyroid gland.<ref name=pmid21644012>{{Cite journal  | last1 = Beach | first1 = DF. | last2 = Klump | first2 = WJ. | last3 = Haddad | first3 = G. | last4 = Reid | first4 = LM. | last5 = Schwarting | first5 = R. | last6 = Hageboutros | first6 = A. | title = Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. | journal = Med Oncol | volume =  | issue =  | pages =  | month = Jun | year = 2011 | doi = 10.1007/s12032-011-9996-7 | PMID = 21644012 }}</ref>
==General==
Classic tumour with paraneoplastic syndromes - may be associated with:<ref name=pmid18316005>{{Cite journal  | last1 = Sher | first1 = T. | last2 = Dy | first2 = GK. | last3 = Adjei | first3 = AA. | title = Small cell lung cancer. | journal = Mayo Clin Proc | volume = 83 | issue = 3 | pages = 355-67 | month = Mar | year = 2008 | doi =  | PMID = 18316005 }}</ref>
*Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
**Clinical: hyponatremia.
*Paraneoplastic cerebellar degeneration.
*Lambert-Eaton myasthenic syndrome.


==Microscopic==
==Microscopic==

Revision as of 20:34, 4 December 2011

Small cell carcinoma is a type of carcinoma. It is mostly commonly from the lung ~95% of cases.[1]

Overview

Grouping

May be grouped as:[1]

Sites other than lung

General

Classic tumour with paraneoplastic syndromes - may be associated with:[4]

  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
    • Clinical: hyponatremia.
  • Paraneoplastic cerebellar degeneration.
  • Lambert-Eaton myasthenic syndrome.

Microscopic

Features:

  • Small cells -- typically 15-20 micrometers ~ 2x the size of RBC.
  • Scant cytoplasm.
  • Stippled chromatin.
  • +/-Nuclear moulding.

Images:

DDx:

See also

References

  1. 1.0 1.1 Grossman, RA.; Pedroso, FE.; Byrne, MM.; Koniaris, LG.; Misra, S. (May 2011). "Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?". J Surg Oncol. doi:10.1002/jso.21976. PMID 21618245.
  2. Cesaretti, M.; Guarnieri, A.; Gaggelli, I.; Tirone, A.; Francioli, N.; Carli, AF.. "Small cell carcinoma of the breast. Report of a case.". Ann Ital Chir 82 (1): 61-4. PMID 21657157.
  3. Beach, DF.; Klump, WJ.; Haddad, G.; Reid, LM.; Schwarting, R.; Hageboutros, A. (Jun 2011). "Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland.". Med Oncol. doi:10.1007/s12032-011-9996-7. PMID 21644012.
  4. Sher, T.; Dy, GK.; Adjei, AA. (Mar 2008). "Small cell lung cancer.". Mayo Clin Proc 83 (3): 355-67. PMID 18316005.