Sickle cell disease
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Sickle cell disease, also sickle cell anemia, is a heritable haematologic disorder associated with serious pathologies.
Red blood cells
- Sickled red blood cells (drepanocytes).
Liver
Main article: Liver
Images
Sickle cell disease and cirrhosis - intermed. mag. (WC)
Sickle cell disease and cirrhosis - high mag. (WC)
Sickle cell disease and cirrhosis - very high mag. (WC)
Spleen
Main article: Spleen
- It may lead to auto infarction - result in hypofunction.
- Splenectomy have increased risk from polysaccharide encapsulated bacteria, i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.
Gallbladder
Main article: Gallbladder
- Pigment stones.
Kidney
- Renal medullary carcinoma associated with sickle cell trait (heterozygotes for the sickle cell allele[2]) or sickle cell disease.
- Papillary necrosis.[2]
- Nephrotic syndrome.[2]
- Renal infarction.[2]
- Pyelonephritis.[2]
Femoral head
See also
References
- ↑ Hurtova, M.; Bachir, D.; Lee, K.; Calderaro, J.; Decaens, T.; Kluger, MD.; Zafrani, ES.; Cherqui, D. et al. (Apr 2011). "Transplantation for liver failure in patients with sickle cell disease: challenging but feasible.". Liver Transpl 17 (4): 381-92. doi:10.1002/lt.22257. PMID 21445921.
- ↑ 2.0 2.1 2.2 2.3 2.4 Davis CJ, Mostofi FK, Sesterhenn IA (January 1995). "Renal medullary carcinoma. The seventh sickle cell nephropathy". Am. J. Surg. Pathol. 19 (1): 1–11. PMID 7528470.