Short power list

The short power list is a short differential diagnosis for the most common specimens.

Breast pathology

Benign:

• Normal.
• Fibroadenoma.
• Fibrocystic change.
• Columnar cell change.

Malignant:

• DCIS.
• LCIS.
• Ductal carcinoma.
• Lobular carcinoma.
• Tubular carcinoma.

Uncommon benign/malignant:

• Phyllodes tumour.

Cardiovascular pathology

General

• Thrombosis (embolism).
• Vasculitis.

Uncommon:

• Amyloid deposition.
• Hyperplastic arteriolosclerosis.

Aorta

• Atherosclerosis.
• Cystic medial degeneration.

Aortic valve

• Calcific aortic stenosis.

Uncommon:

• Endocarditis.
• Myxomatous degeneration.
• Papillary fibroelastoma.

Mitral valve

• Rheumatic heart disease.

Uncommon:

• Myxomatous degeneration.

Heart

• Atrial myxoma.

Uncommon:

• Lipoma.
• Rhabdomyoma.
• Pleomorphic undifferentiated sarcoma.

Gastrointestinal pathology

Appendix

Benign:

• Appendicitis.
• Periappendicitis.
• Crohn's disease.
• Normal.

Neoplasm/malignant:

• Neuroendocrine tumour.
• Low-grade appendiceal mucinous neoplasm (LAMN).
• Mucinous adenocarcinoma.

Gallbladder

Benign:

• Cholelithiasis.
• Cholesterolosis.
• Acute cholecystitis.
• Chronic cholecystitis.

Uncommon - pre-malignant:

• Intestinal metaplasia.

Uncommon - malignant:

• Adenocarcinoma.

Gastrointestinal polyp

Benign:

• Normal.
• Hyperplastic polyp.
• Inflammatory pseudopolyp (inflammatory bowel disease).

Pre-malignant:

• Tubular adenoma.
• Villous adenoma.
• Tubulovillous adenoma.
• Sessile serrated adenoma.

Uncommon - pre-malignant:

• Traditional serrated adenoma.

Stomach

Benign:

• Helicobacter pylori gastritis.
• Intestinal metaplasia.
• Chronic inflammation.
• Acute inflammation.

Pre-malignant:

• Dysplasia.

Malignant:

• Adenocarcinoma, intestinal type.
• Signet-ring cell carcinoma.
• GIST.

Duodenum

Benign:

• Normal.
• Celiac disease.

Pre-malignant:

• Tubular adenoma.

Malignant:

• Adenocarcinoma.

Uncommon benign:

• Giardiasis.
• Whipple disease.
• MAI infection.

Liver

Benign:

• Steatosis.
• Steatohepatitis.
• Hepatitis B.
• Hepatitis C.

Malignant:

• Metastatic adenocarcinoma.
• Hepatocellular carcinoma.

Uncommon benign:

• Autoimmune hepatitis.
• Primary sclerosing cholangitis, esp. in the context of UC.
• Primary biliary cirrhosis.

Uncommon malignant:

• Cholangiocarcinoma.

Genitourinary pathology

Tumour kidney

Benign:

• Normal.
• Renal oncocytoma.
• Angiomyolipoma.
• Papillary adenoma.

Malignant:

• Clear cell renal cell carcinoma.
• Papillary renal cell carcinoma.
• Chromophobe renal cell carcinoma.

Uncommon - benign:

• Xanthogranulomatous pyelonephritis.

Medical kidney

• Diabetic nephropathy.
• Systemic lupus erythematosus.

Prostate gland

Benign:

• Normal.
• Chronic inflammation.
• Acute inflammation.
• Benign prostatic hyperplasia (prostectomy diagnosis only).

Malignant:

• Acinar adenocarcinoma.

Uncommon - malignant:

• Ductal adenocarcinoma.
• Urothelial carcinoma.

Urinary bladder

Benign:

• Inverted urothelial papilloma.
• Cystitis cystica.

Pre-malignant/malignant:

• Urothelial dysplasia.
• Papillary urothelial carcinoma, low grade.
• Papillary urothelial carcinoma, high grade.
• Flat urothelial carcinoma.

Uncommon - benign:

• Malakoplakia.
• Nephrogenic adenoma.

Thyroid gland

Benign:

• Nodular hyperplasia.
• Lymphocytic thyroiditis.

Malignant:

• Papillary thyroid carcinoma.

Gynecologic pathology

Uterus

Benign:

• Fibroids.
• Adenomyosis.
• Atrophy.
• Prolapse.
• Proliferative phase endometrium.
• Secretory phase endometrium.

Pre-malignant:

• Complex endometrial hyperplasia.

Malignant:

• Endometrial carcinoma.
  • Endometrioid.
  • Mucinous.
  • Serous.

Uncommon - malignant:

• Clear cell carcinoma.
• Carcinosarcoma.

Cervix - cytology

Benign:

• Normal.
• Candida.
• Endometrial cells.
• Atrophy.

Pre-malignant/malignant:

• LSIL.
• HSIL.
• Squamous cell carcinoma.
• Adenocarcinoma.

Uncommon - benign:

• HSV changes.
• Trichomonas.

Ovary

Benign:

• Serous cystadenoma.
• Mucinous cystadenoma.
• Mature teratoma.
• Endometriosis.

Malignant:

• Serous carcinoma.
• Endometrioid carcinoma.
• Mucinous carcinoma.

Lymph node

Benign:

• Normal/resting.
• Follicular hyperplasia.

Malignant:

• Metastasis, esp. carcinoma.
• Follicular lymphoma.
• Diffuse large B cell lymphoma.
• Nodular sclerosis Hodgkin lymphoma.
• Mixed cellularity Hodgkin lymphoma.

Head and neck

Benign:

• Sinonasal papilloma.
• Vocal cord nodule.

Malignant:

• Squamous cell carcinoma.
• Nasopharyngeal carcinoma.

Adrenal gland

Benign:

• Adrenal cortical adenoma.

Malignant:

• Adrenal cortical carcinoma.
• Pheochromocytoma.

See also

• Diagnosis.