Sertoli cell nodule
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| Sertoli cell nodule | |
|---|---|
| Diagnosis in short | |
 Sertoli cell nodule. H&E stain. | |
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| |
| Synonyms | Pick's adenoma, testicular tubular adenoma, tubular adenoma of the testis |
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| LM | unencapsulated nodules composed of well-formed tubules, +/eosinophilic (hyaline) blob in lumen (centre), cells - vaguely resemble immature Sertoli cells (bland hyperchromatic oval/round nuclei) but are stratified (somewhat like a tubular adenoma of the gastrointestinal tract) |
| LM DDx | Sertoli cell tumour, sex cord tumour with annular tubules, gonadoblastoma |
| IHC | alpha-inhibin +ve, PLAP -ve |
| Site | testis |
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| |
| Clinical history | +/-undescended testis |
| Prevalence | uncommon in general |
Sertoli cell nodule, abbreviated SCN, is a benign lesion of the testis that is usually incidental.
It is also known as Pick's adenoma, testicular tubular adenoma and tubular adenoma of the testis.
General
- Benign proliferation of Sertoli cells - associated with cryptorchidism (undescended testis).
- Not composed of a clonal cell population, i.e. not neoplastic; thus, technically, should not be called an adenoma.[1]
Gross
- Usually an incidental finding, rarely presents as a testicular mass.[2]
Microscopic
- Unencapsulated nodules composed of well-formed tubules.
- May contain eosinophilic (hyaline) blob in lumen (centre).
- Cells - vaguely resemble immature Sertoli cells:
- Bland hyperchromatic oval/round nuclei that are stratified - somewhat like a tubular adenoma of the gastrointestinal tract - key feature.
DDx:[2]
Images
Sertoli cell nodule - high mag. (WC)
Sertoli cell nodule - low mag. (WC)
IHC
Features:[2]
- Alpha-inhibin +ve (5/5 cases).
- OCT3/4 -ve (5/5 cases).
Other:
- PLAP -ve.
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TESTICLE, LEFT, ORCHIECTOMY: - ATROPHIC TESTICLE WITH SERTOLI CELL NODULES. - NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA). - NEGATIVE FOR MALIGNANCY. COMMENT: The above findings are supported by immunostains. The tubules stain with alpha-inhibin and are negative for PLAP.
See also
References
- ↑ 1.0 1.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 227. ISBN 978-0470519035.
- ↑ 2.0 2.1 2.2 Vallangeon, BD.; Eble, JN.; Ulbright, TM. (Dec 2010). "Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses.". Am J Surg Pathol 34 (12): 1874-80. doi:10.1097/PAS.0b013e3181fcab70. PMID 21107095.
- ↑ Ricco R, Bufo P (October 1980). "[Histologic study of 3 cases of so-called tubular adenoma of the testis]" (in Italian). Boll. Soc. Ital. Biol. Sper. 56 (20): 2110–5. PMID 6109541.