Difference between revisions of "Serous tubal intraepithelial carcinoma"

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| Image      = Serous tubal intraepithelial carcinoma -- low mag.jpg
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| Caption    = Micrograph showing serous tubal intraepithelial carcinoma. [[H&E stain]].
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| Molecular  = BRCA1 mutation or BRCA2 mutation
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| Site      = [[fallopian tubes]]
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| Symptoms  = none
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| Prevalence = uncommon
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'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]].
 
'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]].
  

Revision as of 00:13, 1 January 2020

Serous tubal intraepithelial carcinoma
Diagnosis in short

Micrograph showing serous tubal intraepithelial carcinoma. H&E stain.
Molecular BRCA1 mutation or BRCA2 mutation
Site fallopian tubes

Symptoms none
Prevalence uncommon

Serous tubal intraepithelial carcinoma, abbreviated STIC[1] (pronounced stick), is considered to be the precursor of serous carcinoma.

It is also known as tubal intraepithelial carcinoma.

General

  • Considered the precursor lesion for tubal serous carcinoma.[2]
  • Seen in ~6% of prophylactic salpingo-oophorectomies in BRCA-mutation carriers.[3]

Gross

  • Not apparent on gross.
  • Usually at the fimbriated end of the tube.

Microscopic

Features:[4]

  • Discrete papillary growth - low power.
  • Formal criteria - need 3 or more:
    1. Atypical chromatin pattern.
    2. Nuclear enlargement.
    3. Nuclear pleomorphism.
    4. Nuclear moulding.
    5. Loss of nuclear polarity or epithelial stratification.

Notes:

  • At low power STIC is usually tall cells that are too blue.
  • Cilia suggest benign.

DDx:

  • Atypical tubal lesion (STIL or TILT) - lack proliferation.[citation needed]

Images

www

IHC

Features:[1]

  • p53 +ve.
  • Ki-67 increased ~10%. (???)
  • p16 +ve.[4]

See also

References

  1. 1.0 1.1 Visvanathan, K.; Vang, R.; Shaw, P.; Gross, A.; Soslow, R.; Parkash, V.; Shih, IeM.; Kurman, RJ. (Dec 2011). "Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study.". Am J Surg Pathol 35 (12): 1766-75. doi:10.1097/PAS.0b013e31822f58bc. PMID 21989347.
  2. Lee, Y.; Miron, A.; Drapkin, R.; Nucci, MR.; Medeiros, F.; Saleemuddin, A.; Garber, J.; Birch, C. et al. (Jan 2007). "A candidate precursor to serous carcinoma that originates in the distal fallopian tube.". J Pathol 211 (1): 26-35. doi:10.1002/path.2091. PMID 17117391.
  3. Mingels MJ, Roelofsen T, van der Laak JA, et al. (October 2012). "Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls". Gynecol. Oncol. 127 (1): 88–93. doi:10.1016/j.ygyno.2012.06.015. PMID 22710074.
  4. 4.0 4.1 4.2 Sehdev, AS.; Kurman, RJ.; Kuhn, E.; Shih, IeM. (Jun 2010). "Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.". Mod Pathol 23 (6): 844-55. doi:10.1038/modpathol.2010.60. PMID 20228782.
  5. 5.0 5.1 5.2 Kurman, RJ.; Shih, IeM. (Jul 2011). "Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm.". Hum Pathol 42 (7): 918-31. doi:10.1016/j.humpath.2011.03.003. PMID 21683865.
  6. Gross, AL.; Kurman, RJ.; Vang, R.; Shih, IeM.; Visvanathan, K. (2010). "Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics.". J Oncol 2010: 126295. doi:10.1155/2010/126295. PMID 20445756.
  7. URL: http://www.ovariancancerprevention.org/?page_id=191. Accessed on: 13 May 2014.

External links