Secretory carcinoma of the salivary gland

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Secretory carcinoma of the salivary gland
Diagnosis in short

Secretory carcinoma of the salivary gland. H&E stain. (WC/NormanDy)

Synonyms Mammary analogue secretory carcinoma (previous name)

LM large cells with abundant cytoplasm, small nuclei, +/-lymphocytic infiltrate, solid and microcystic growth pattern
LM DDx acinic cell carcinoma, mucoepidermoid carcinoma
Stains PAS +ve
IHC S-100 +ve, mammaglobin +ve, vimentin +ve
Molecular ETV6-NTRK3 fusion gene
Site salivary gland - usually parotid

Prevalence rare
Clin. DDx other salivary gland tumours
Treatment excision

Secretory carcinoma of the salivary gland is an uncommon malignant salivary gland tumour that was first described in 2010.[1]

It was previously known as mammary analogue secretory carcinoma, abbreviated MASC.[2]


  • Microscopic appearance similar to secretory breast carcinoma.[3]
  • Rare - 21 cases in the world literature as of 2012.[1]
  • Original paper described it only in adults.[3]
    • Has been described in a pediatric patient.[4]




  • Large cells with abundant cytoplasm.
  • Small nuclei.
  • +/-Lymphocytic infiltrate.
  • Solid and microcystic growth pattern.
  • +/-Cystic changes lined by hobnail cells - useful feature.



Case 1

Case 2






  • S-100 +ve.[1]
  • Mammaglobin +ve.
  • Vimentin +ve.


  • p63 -ve.
    • Unusual in mucoepidermoid carcinoma.
  • HMWCK -ve.
  • GATA3 +ve.


  • S-100, mammaglobin, p63, HMWCK.



  • t(12;15)(p13;q25).


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Right Parotid Lesion, Core Biopsy:
     - SECRETORY CARCINOMA of the salivary gland, see comment.

Secretory carcinoma of the salivary gland was previously known as "mammary analogue secretory carcinoma" (MASC).

The tumour stains as follows:
POSITIVE: CK7 (strong, diffuse), mammaglobin (strong, diffuse), S100 (moderate, patchy), mucin (focal).

NTRK testing was ordered; the results will be reported in an addendum.


The sections show a cohesive tumor with moderate amphophilic cytoplasm and vacuolation. The vacuolation is focally prominent. Nucleoli are inconspicuous. Poorly formed glands are present. Keratinization is absent.

See also


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. Montalvo N, Galarza D, Redrobán L (2019). "Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available". Case Rep Pathol 2019: 5103496. doi:10.1155/2019/5103496. PMC 6441535. PMID 31007960.
  3. 3.0 3.1 3.2 3.3 3.4 Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.
  4. Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.