Difference between revisions of "Secretory carcinoma of the salivary gland"

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*[[Salivary gland]].
 
*[[Salivary gland]].
 
*[[Secretory breast carcinoma]].
 
*[[Secretory breast carcinoma]].
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*[[Secretory carcinoma]].
  
 
==References==
 
==References==

Revision as of 10:16, 31 December 2019

Secretory carcinoma of the salivary gland
Diagnosis in short

Secretory carcinoma of the salivary gland. H&E stain. (WC/NormanDy)

Synonyms Mammary analogue secretory carcinoma (previous name)

LM large cells with abundant cytoplasm, small nuclei, +/-lymphocytic infiltrate, solid and microcystic growth pattern
LM DDx acinic cell carcinoma, mucoepidermoid carcinoma
Stains PAS +ve
IHC S-100 +ve, mammaglobin +ve, vimentin +ve
Molecular ETV6-NTRK3 fusion gene
Site salivary gland - usually parotid

Prevalence rare
Clin. DDx other salivary gland tumours
Treatment excision

Secretory carcinoma of the salivary gland is rare a newly described malignant salivary gland tumour.[1]

It was previously known as mammary analogue secretory carcinoma, abbreviated MASC.[2]

General

  • Microscopic appearance similar to secretory breast carcinoma.[3]
  • Rare - 21 cases in the world literature as of 2012.[1]
  • Original paper described it only in adults.[3]
    • Has been described in a pediatric patient.[4]

Gross

Microscopic

Features:

  • Large cells with abundant cytoplasm.
  • Small nuclei.
  • +/-Lymphocytic infiltrate.
  • Solid and microcystic growth pattern.
  • +/-Cystic changes lined by hobnail cells - useful feature.

DDx:

Images

www

Stains

Features:[3]

IHC

Features:[3]

  • S-100 +ve.[1]
  • Mammaglobin +ve.
  • Vimentin +ve.

Others:

  • p63 -ve.
    • Unusual in mucoepidermoid carcinoma.
  • HMWCK -ve.
  • GATA3 +ve.

Panel:

  • S-100, mammaglobin, p63, HMWCK.

Images

Molecular

  • t(12;15)(p13;q25).

Note:

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. "Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available". Case Rep Pathol 2019: 5103496. 2019. doi:10.1155/2019/5103496. PMC 6441535. PMID 31007960. //www.ncbi.nlm.nih.gov/pmc/articles/PMC6441535/.
  3. 3.0 3.1 3.2 3.3 3.4 Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.
  4. Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.