Sclerosing mucoepidermoid carcinoma with eosinophilia

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Sclerosing mucoepidermoid carcinoma with eosinophilia is an extremely rare tumour of the thyroid gland.

General

Associated with:

Microscopic

Features:

  • Mucous cells
  • Squamoid differentiation.

DDx:

Stains

  • Mucin stains +ve.

IHC

  • TTF-1 +ve
  • Thyroglobulin -ve.
  • PAX8 +ve.
  • Calcitonin -ve.

Molecular

  • Negative for MAML2 rearrangements.[1]

See also

References

  1. ↑ Shah, AA.; La Fortune, K.; Miller, C.; Mills, SE.; Baloch, Z.; LiVolsi, V.; Dacic, S.; Mahaffey, AL. et al. (Mar 2017). "Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.". Mod Pathol 30 (3): 329-339. doi:10.1038/modpathol.2016.180. PMID 27910944.
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