Sarcomatoid urothelial carcinoma
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
| Sarcomatoid urothelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Sarcomatoid urothelial carcinoma. H&E stain. | |
| Subtypes | (subtype of urothelial carcinoma) |
| LM DDx | sarcoma, carcinosarcoma - esp. in women, other sarcomatoid carcinomas, collision tumour |
| IHC | GATA3 +ve |
| Site | urothelium - urinary bladder, ureter, renal pelvis |
|
| |
| Prevalence | very rare |
| Prognosis | poor |
| Treatment | resection if feasible |
Sarcomatoid urothelial carcinoma (abbreviated sarcomatoid UC), also sarcomatoid urothelial cell carcinoma (abbreviated sarcomatoid UCC), is a rare variant of urothelial carcinoma.[1]
General
- Rare[1] approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.[2]
- Aggressive >55% dead within one year of presentation.[1]
Gross
Microscopic
Features:
- Urothelial carcinoma (classic or recognizable variant).
- Sarcomatoid differentiation - typically (undifferentiated) spindle cells.
- Approximately have 10% of heterologous elements,[1] e.g. chondrosarcomatous differentiation, osteosarcomatous differentiation.
DDx:
- Sarcoma - esp. those arising from the retroperitoneum.
- Carcinosarcoma - esp. in women.
- Other sarcomatoid carcinomas, e.g. sarcomatoid prostate carcinoma.
- Collision tumour (rare) - components should not intermingle.
Images
Sarcomatoid UCC - low mag.
Sarcomatoid UCC - intermed. mag.
Sarcomatoid UCC - high mag.
IHC
- GATA3 +ve (16 +ve of 22 cases[5]).
See also
References
- ↑ 1.0 1.1 1.2 1.3 Fatima, N.; Canter, DJ.; Carthon, BC.; Kucuk, O.; Master, VA.; Nieh, PT.; Ogan, K.; Osunkoya, AO. (Jun 2015). "Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases.". Can J Urol 22 (3): 7783-7. PMID 26068625.
- ↑ Wang, J.; Wang, FW.; Lagrange, CA.; Hemstreet Iii, GP.; Kessinger, A. (2010). "Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases.". Sarcoma 2010. doi:10.1155/2010/454792. PMID 20706685.
- ↑ Nicolas, MM.; Nazarullah, A.; Guo, CC. (Apr 2014). "Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: a case report.". Anal Quant Cytopathol Histpathol 36 (2): 111-6. PMID 24902363.
- ↑ Tian, X.; Zhao, J.; Wang, Y.; Xing, N. (Sep 2014). "Sarcomatoid carcinoma of the renal pelvis: A case report.". Oncol Lett 8 (3): 1208-1210. doi:10.3892/ol.2014.2240. PMID 25120689.
- ↑ Fatima, N.; Osunkoya, AO. (Aug 2014). "GATA3 expression in sarcomatoid urothelial carcinoma of the bladder.". Hum Pathol 45 (8): 1625-9. doi:10.1016/j.humpath.2014.03.015. PMID 24824028.