Difference between revisions of "SMARCA4-deficient non-small cell carcinoma of the lung"

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*Hepatoid [[adenocarcinoma of lung]] shows cytoplasmic [[TTF-1]] staining.<ref name=pmid24030743>{{Cite journal  | last1 = Haninger | first1 = DM. | last2 = Kloecker | first2 = GH. | last3 = Bousamra Ii | first3 = M. | last4 = Nowacki | first4 = MR. | last5 = Slone | first5 = SP. | title = Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature. | journal = Mod Pathol | volume = 27 | issue = 4 | pages = 535-42 | month = Apr | year = 2014 | doi = 10.1038/modpathol.2013.170 | PMID = 24030743 }}</ref>
 
*Hepatoid [[adenocarcinoma of lung]] shows cytoplasmic [[TTF-1]] staining.<ref name=pmid24030743>{{Cite journal  | last1 = Haninger | first1 = DM. | last2 = Kloecker | first2 = GH. | last3 = Bousamra Ii | first3 = M. | last4 = Nowacki | first4 = MR. | last5 = Slone | first5 = SP. | title = Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature. | journal = Mod Pathol | volume = 27 | issue = 4 | pages = 535-42 | month = Apr | year = 2014 | doi = 10.1038/modpathol.2013.170 | PMID = 24030743 }}</ref>
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==Sign out==
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<pre>
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The tumour stains as follows:
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POSITIVE: CK7 (diffuse, strong), HepPar-1 (strong, diffuse).
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NEGATIVE: TTF-1, napsin A, p63, CK5/6.
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The staining pattern for this tumour is not typical for lung adenocarcinoma; please correlate with the clinical findings.
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HepPar-1 POSITIVITY with CK7 POSITIVITY and TTF-1 NEGATIVITY may be seen in SMARCA4-deficient adenocarcinoma of the lung.[1]
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1. Virchows Arch 471 (5): 599-609. doi:10.1007/s00428-017-2148-5. PMID 28555282.
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</pre>
  
 
==See also==
 
==See also==

Latest revision as of 14:18, 24 October 2019

SMARCA4-deficient non-small cell carcinoma of the lung is an emerging subtype of lung cancer.[1]

General

  • ~5.1% of non-small cell carcinoma is SMARCA4 deficient in a series of 316 cases.[2]
  • May represent or overlap with what is known as hepatoid adenocarcinoma of the lung.[citation needed]

IHC

Features:[1]

  • CK7 +ve.
  • TTF-1 -ve.
  • HepPar-1 +ve (15/20 +ve, 2/20 isolated +ve cells, 3/20 -ve).[1]
  • SMARCA4 -ve.

Note:

Sign out

The tumour stains as follows: 
POSITIVE: CK7 (diffuse, strong), HepPar-1 (strong, diffuse).
NEGATIVE: TTF-1, napsin A, p63, CK5/6.

The staining pattern for this tumour is not typical for lung adenocarcinoma; please correlate with the clinical findings.

HepPar-1 POSITIVITY with CK7 POSITIVITY and TTF-1 NEGATIVITY may be seen in SMARCA4-deficient adenocarcinoma of the lung.[1]

1. Virchows Arch 471 (5): 599-609. doi:10.1007/s00428-017-2148-5. PMID 28555282.

See also

References

  1. 1.0 1.1 1.2 Agaimy, A.; Fuchs, F.; Moskalev, EA.; Sirbu, H.; Hartmann, A.; Haller, F. (Nov 2017). "SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1". Virchows Arch 471 (5): 599-609. doi:10.1007/s00428-017-2148-5. PMID 28555282.
  2. Herpel, E.; Rieker, RJ.; Dienemann, H.; Muley, T.; Meister, M.; Hartmann, A.; Warth, A.; Agaimy, A. (Feb 2017). "SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.". Ann Diagn Pathol 26: 47-51. doi:10.1016/j.anndiagpath.2016.10.006. PMID 28038711.
  3. Haninger, DM.; Kloecker, GH.; Bousamra Ii, M.; Nowacki, MR.; Slone, SP. (Apr 2014). "Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature.". Mod Pathol 27 (4): 535-42. doi:10.1038/modpathol.2013.170. PMID 24030743.