Difference between revisions of "SMARCA4-deficient non-small cell carcinoma of the lung"

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m (Michael moved page SMARCA4-deficient adenocarcinoma of the lung to SMARCA4-deficient non-small cell carcinoma of the lung: also seen in squamous cell ca of lung)
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'''SMARCA4-deficient adenocarcinoma of the lung''' is an emerging subtype of [[lung adenocarcinoma]].<ref name=pmid28555282>{{Cite journal  | last1 = Agaimy | first1 = A. | last2 = Fuchs | first2 = F. | last3 = Moskalev | first3 = EA. | last4 = Sirbu | first4 = H. | last5 = Hartmann | first5 = A. | last6 = Haller | first6 = F. | title = SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1 | journal = Virchows Arch | volume = 471 | issue = 5 | pages = 599-609 | month = Nov | year = 2017 | doi = 10.1007/s00428-017-2148-5 | PMID = 28555282 }}</ref>
'''SMARCA4-deficient non-small cell carcinoma of the lung''' is an emerging subtype of [[lung cancer]].<ref name=pmid28555282>{{Cite journal  | last1 = Agaimy | first1 = A. | last2 = Fuchs | first2 = F. | last3 = Moskalev | first3 = EA. | last4 = Sirbu | first4 = H. | last5 = Hartmann | first5 = A. | last6 = Haller | first6 = F. | title = SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1 | journal = Virchows Arch | volume = 471 | issue = 5 | pages = 599-609 | month = Nov | year = 2017 | doi = 10.1007/s00428-017-2148-5 | PMID = 28555282 }}</ref>


==General==
==General==

Revision as of 20:55, 14 November 2018

SMARCA4-deficient non-small cell carcinoma of the lung is an emerging subtype of lung cancer.[1]

General

  • ~5.1% of non-small cell carcinoma is SMARCA4 deficient in a series of 316 cases.[2]

IHC

Features:[1]

  • CK7 +ve.
  • TTF-1 -ve.
  • HepPar-1 +ve.
  • SMARCA4 -ve.

See also

References

  1. ↑ 1.0 1.1 Agaimy, A.; Fuchs, F.; Moskalev, EA.; Sirbu, H.; Hartmann, A.; Haller, F. (Nov 2017). "SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1". Virchows Arch 471 (5): 599-609. doi:10.1007/s00428-017-2148-5. PMID 28555282.
  2. ↑ Herpel, E.; Rieker, RJ.; Dienemann, H.; Muley, T.; Meister, M.; Hartmann, A.; Warth, A.; Agaimy, A. (Feb 2017). "SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.". Ann Diagn Pathol 26: 47-51. doi:10.1016/j.anndiagpath.2016.10.006. PMID 28038711.
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