Radiation oncology

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Radiation oncology is a place where people go after the pathologist has diagnosed it as cancer.

Dose

Measured with several units.

Gray

Abbreviated Gy.
Energy/mass.

$1\ \mathrm {Gy} =1\ {\frac {\mathrm {J} }{\mathrm {kg} }}=1\ \mathrm {m} ^{2}\cdot \mathrm {s} ^{-2}$

Sievert

Abbreviated Sv.
"Biologic effect"/mass.^[1]

$Sv=X\cdot dose$

Where:

X = fiddle factor for type of tissue and type of radiation.
dose = dose in Gray.

Typical doses

Single dose:^[1]

<0.5 Gy no histologic change.
1-2 Gy proliferating cells die.
10 Gy overt necrosis.

Total:

Solid tumours ~ 60 to 80 Gy.
Lymphoma ~ 20 to 40 Gy.

Biology

DNA damage is thought to depend on reactive oxygen species.
- Therefore, poorly oxygenated and poorly vascularized tissues are less sensitive to radiation exposures/treatments.^[1]

References

↑ ^1.0 ^1.1 ^1.2 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 222. ISBN 978-1416054542.

External links

Radiation oncology (wikibooks.org) - has substantial content and includes the AJCC staging.

[Ref_PCPBoD8_222-1] 1.0 ^1.1 ^1.2 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 222. ISBN 978-1416054542.

[1]

Radiation oncology

Contents