Radiation oncology

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Radiation oncology is a place where people go after the pathologist has diagnosed it as cancer.

Dose

  • Measure with several units.

Gray

  • Abbreviated Gy.
  • Energy/mass.

Sievert

  • Abbreviated Sv.
  • "Biologic effect"/mass.[1]

Where:

  • X = fiddle factor for type of tissue and type of radiation.
  • dose = dose in Gray.

Typical doses

Single dose:[1]

  • <0.5 Gy no histologic change.
  • 1-2 Gy proliferating cells die.
  • 10 Gy overt necrosis.

Total:

  • Solid tumours ~ 60 to 80 Gy.
  • Lymphoma ~ 20 to 40 Gy.

Biology

  • DNA damage is thought to depend on reactive oxygen species.
    • Therefore, poorly oxygenated and poorly vascularized tissues are less sensitive to radiation exposures/treatments.[1]

See also

References

  1. 1.0 1.1 1.2 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 222. ISBN 978-1416054542.

External links