Difference between revisions of "Radiation oncology"

From Libre Pathology
Jump to navigation Jump to search
m
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Radiation oncology''' is a place where people go after the pathologist has called it cancer.
'''Radiation oncology''' is a place where people go after the [[pathologist]] has [[diagnosis|diagnosed]] it as [[cancer]].


==Dose==
==Dose==
*Measure with several units.
*Measured with several units.


===Gray===
===Gray===
Line 12: Line 12:
===Sievert===
===Sievert===
*Abbreviated ''Sv''.
*Abbreviated ''Sv''.
*"Biologic effect"/mass.<ref>{{Ref PCPBoD8|222}}</ref>
*"Biologic effect"/mass.<ref name=Ref_PCPBoD8_222>{{Ref PCPBoD8|222}}</ref>


<math>Sv = X \cdot dose</math>
<math>Sv = X \cdot dose</math>
Line 20: Line 20:
*dose = dose in Gray.
*dose = dose in Gray.


===Typical total dose===
===Typical doses===
Single dose:<ref name=Ref_PCPBoD8_222>{{Ref PCPBoD8|222}}</ref>
*<0.5 Gy no histologic change.
*1-2 Gy proliferating cells die.
*10 Gy overt necrosis.
 
Total:
*Solid tumours ~ 60 to 80 Gy.
*Solid tumours ~ 60 to 80 Gy.
*Lymphoma ~ 20 to 40 Gy.
*[[Lymphoma]] ~ 20 to 40 Gy.
 
==Biology==
*DNA damage is thought to depend on reactive oxygen species.
**Therefore, poorly oxygenated and poorly vascularized tissues are less sensitive to radiation exposures/treatments.<ref name=Ref_PCPBoD8_222>{{Ref PCPBoD8|222}}</ref>


==See also==
==See also==
*[[Oncology]].
*[[Oncology]].
*[[Radiation colitis]].
*[[Radiation changes]].


==References==
==References==
{{Reflist|1}}
{{Reflist|1}}
==External links==
*[http://en.wikibooks.org/wiki/Radiation_Oncology Radiation oncology (wikibooks.org)] - has substantial content and includes the AJCC staging.


[[Category:Clinical]]
[[Category:Clinical]]

Latest revision as of 12:31, 8 October 2013

Radiation oncology is a place where people go after the pathologist has diagnosed it as cancer.

Dose

  • Measured with several units.

Gray

  • Abbreviated Gy.
  • Energy/mass.

Sievert

  • Abbreviated Sv.
  • "Biologic effect"/mass.[1]

Where:

  • X = fiddle factor for type of tissue and type of radiation.
  • dose = dose in Gray.

Typical doses

Single dose:[1]

  • <0.5 Gy no histologic change.
  • 1-2 Gy proliferating cells die.
  • 10 Gy overt necrosis.

Total:

  • Solid tumours ~ 60 to 80 Gy.
  • Lymphoma ~ 20 to 40 Gy.

Biology

  • DNA damage is thought to depend on reactive oxygen species.
    • Therefore, poorly oxygenated and poorly vascularized tissues are less sensitive to radiation exposures/treatments.[1]

See also

References

  1. 1.0 1.1 1.2 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 222. ISBN 978-1416054542.

External links