Pyloric gland adenoma

From Libre Pathology
Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Pyloric gland adenoma
Diagnosis in short

LM foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia
LM DDx foveolar-type gastric adenoma, well-differentiated gastric adenocarcinoma
IHC MUC6 +ve, MUC5AC +ve, Ki-67 high
Site stomach, duodenum, gallbladder, others

Associated Dx well-differentiated gastric adenocarcinoma, autoimmune gastritis
Prevalence uncommon
Endoscopy polyp
Prognosis benign
Clin. DDx other polyps
Treatment excision

Pyloric gland adenoma, abbreviated PGA, is an uncommon gastrointestinal lesion.

General

Microscopic

Features:[3]

  • Round mildly irregular foveolar-type glands with:
    • Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
    • Moderate eosinophilic (or clear) cytoplasm.

DDx:

Images

IHC

  • Ki-67 high.
  • MUC6 +ve.[3]
    • Negative in foveolar-type gastric adenomas.
  • MUC5AC +ve.[3]

See also

References

  1. Vieth, M.; Vogel, C.; Kushima, R.; Borchard, F.; Stolte, M. (Jan 2006). "Pyloric gland adenoma-- how to diagnose?". Cesk Patol 42 (1): 4-7. PMID 16506593.
  2. Vieth, M.; Montgomery, EA. (Aug 2014). "Some observations on pyloric gland adenoma: an uncommon and long ignored entity!". J Clin Pathol. doi:10.1136/jclinpath-2014-202553. PMID 25092673.
  3. 3.0 3.1 3.2 Chen, ZM.; Scudiere, JR.; Abraham, SC.; Montgomery, E. (Feb 2009). "Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.". Am J Surg Pathol 33 (2): 186-93. doi:10.1097/PAS.0b013e31817d7ff4. PMID 18830123.