Proton pump inhibitor effect

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Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.

Stomach with PPI effect. H&E stain.

Formally, it is stomach with proton pump inhibitor effect.

General

Some proton pump inhibitors

Generic name Brand name(s)
Omeprazole LOSEC
Dexlansoprazole DEXILANT
Lansoprazole PREVACID
Esomeprazole NEXIUM
Pantoprazole PANTOLOC
Rabeprazole PARIET

Microscopic

Features:[1][2]

  • Parietal cell enlargement - key feature.
    • Parietal cells typically bulge into the lumen.
  • G cell and enterochromaffin cell-like hyperplasia.
    • Compensatory change due to increased pH in gastric lumen.
  • Multiple fundic gland polyps (with PPI use over several months).
    • Polyps may regress after PPI is stopped.

Images

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  • Usually not reported.

See also

References

  1. Driman, DK.; Wright, C.; Tougas, G.; Riddell, RH. (Oct 1996). "Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.". Dig Dis Sci 41 (10): 2039-47. PMID 8888719.
  2. topic/stomachPPI.html topic/stomachPPI