Difference between revisions of "Proton pump inhibitor effect"

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==Microscopic==
==Microscopic==
Features:<ref>{{Cite journal  | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi =  | PMID = 8888719 }}</ref>
Features:<ref>{{Cite journal  | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi =  | PMID = 8888719 }}</ref> <ref>{{Pathologyoutlines| topic/stomachPPI}}</ref>
*Parietal cell enlargement - '''key feature'''.
*Parietal cell enlargement - '''key feature'''.
**Parietal cells typically bulge into the lumen.
**Parietal cells typically bulge into the lumen.
*G cell and enterochromaffin cell-like hyperplasia
**Compensatory change due to increased pH in gastric lumen.
*Multiple fundic gland polyps (with PPI use over several months)
**Polyps may regress after PPI is stopped


===Images===
===Images===
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