Difference between revisions of "Proton pump inhibitor effect"

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==Microscopic==
==Microscopic==
Features:<ref>{{Cite journal  | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi =  | PMID = 8888719 }}</ref> <ref>{{Pathologyoutlines| topic/stomachPPI}}</ref>
Features:<ref name=pmid8888719>{{Cite journal  | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi =  | PMID = 8888719 }}</ref><ref>{{Pathologyoutlines| topic/stomachPPI}}</ref>
*Parietal cell enlargement - '''key feature'''.
*Parietal cell enlargement - '''key feature'''.
**Parietal cells typically bulge into the lumen.
**Parietal cells typically bulge into the lumen.
*G cell and enterochromaffin cell-like hyperplasia
*G cell and enterochromaffin cell-like hyperplasia.
**Compensatory change due to increased pH in gastric lumen.
**Compensatory change due to increased pH in gastric lumen.
*Multiple fundic gland polyps (with PPI use over several months)
*Multiple fundic gland polyps (with PPI use over several months).
**Polyps may regress after PPI is stopped
**Polyps may regress after PPI is stopped.


===Images===
===Images===

Latest revision as of 18:36, 2 March 2020

Stomach with PPI effect. H&E stain.

Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.

Formally, it is stomach with proton pump inhibitor effect.

General

Some proton pump inhibitors

Generic name Brand name(s)
Omeprazole LOSEC
Dexlansoprazole DEXILANT
Lansoprazole PREVACID
Esomeprazole NEXIUM
Pantoprazole PANTOLOC
Rabeprazole PARIET

Microscopic

Features:[1][2]

  • Parietal cell enlargement - key feature.
    • Parietal cells typically bulge into the lumen.
  • G cell and enterochromaffin cell-like hyperplasia.
    • Compensatory change due to increased pH in gastric lumen.
  • Multiple fundic gland polyps (with PPI use over several months).
    • Polyps may regress after PPI is stopped.

Images

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  • Usually not reported.

See also

References

  1. Driman, DK.; Wright, C.; Tougas, G.; Riddell, RH. (Oct 1996). "Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.". Dig Dis Sci 41 (10): 2039-47. PMID 8888719.
  2. topic/stomachPPI.html topic/stomachPPI