Difference between revisions of "Proton pump inhibitor effect"

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[[Image:Stomach with prominent parietal cells -- very high mag.jpg|thumb|right|250px|Stomach with PPI effect. [[H&E stain]].]]
'''Proton pump inhibitor effect''', abbreviated '''PPI effect''', is a change seen in the parietal cells of the [[stomach]] due to a drug in the proton pump inhibitor class.
'''Proton pump inhibitor effect''', abbreviated '''PPI effect''', is a change seen in the parietal cells of the [[stomach]] due to a drug in the proton pump inhibitor class.
Formally, it is '''stomach with proton pump inhibitor effect'''.


==General==
==General==
*Due to intake of a proton pump inhibitor (PPI).
*Due to intake of a proton pump inhibitor (PPI).
**Used to treat [[gastroesophageal reflux disease]].
**Used to treat [[gastroesophageal reflux disease]].
===Some proton pump inhibitors===
{| class="wikitable sortable"
! Generic name
! Brand name(s)
|-
|Omeprazole
|LOSEC
|-
|Dexlansoprazole
|DEXILANT
|-
|Lansoprazole
|PREVACID
|-
|Esomeprazole
|NEXIUM
|-
|Pantoprazole
|PANTOLOC
|-
|Rabeprazole
|PARIET
|}


==Microscopic==
==Microscopic==
Features:<ref>{{Cite journal  | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi =  | PMID = 8888719 }}</ref>
Features:<ref name=pmid8888719>{{Cite journal  | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi =  | PMID = 8888719 }}</ref><ref>{{Pathologyoutlines| topic/stomachPPI}}</ref>
*Parietal cell enlargement - '''key feature'''.
*Parietal cell enlargement - '''key feature'''.
**Parietal cells typically bulge into the lumen.
*G cell and enterochromaffin cell-like hyperplasia.
**Compensatory change due to increased pH in gastric lumen.
*Multiple fundic gland polyps (with PPI use over several months).
**Polyps may regress after PPI is stopped.
===Images===
<gallery>
Image: Stomach with prominent parietal cells -- intermed mag.jpg | PPI effect - intermed. mag.
Image: Stomach with prominent parietal cells -- high mag.jpg | PPI effect - high mag.
Image: Stomach with prominent parietal cells -- very high mag.jpg | PPI effect - very high mag.
</gallery>
www:
*[http://www.nature.com/nrgastro/journal/v4/n8/images/ncpgasthep0896-f3.jpg PPI effect (nature.com)].


==Sign out==
==Sign out==
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==See also==
==See also==
*[[Stomach]].
*[[Stomach]].
*[[Glycogenic acanthosis of the esophagus]].


==References==
==References==

Latest revision as of 18:36, 2 March 2020

Stomach with PPI effect. H&E stain.

Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.

Formally, it is stomach with proton pump inhibitor effect.

General

Some proton pump inhibitors

Generic name Brand name(s)
Omeprazole LOSEC
Dexlansoprazole DEXILANT
Lansoprazole PREVACID
Esomeprazole NEXIUM
Pantoprazole PANTOLOC
Rabeprazole PARIET

Microscopic

Features:[1][2]

  • Parietal cell enlargement - key feature.
    • Parietal cells typically bulge into the lumen.
  • G cell and enterochromaffin cell-like hyperplasia.
    • Compensatory change due to increased pH in gastric lumen.
  • Multiple fundic gland polyps (with PPI use over several months).
    • Polyps may regress after PPI is stopped.

Images

www:

Sign out

  • Usually not reported.

See also

References

  1. Driman, DK.; Wright, C.; Tougas, G.; Riddell, RH. (Oct 1996). "Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.". Dig Dis Sci 41 (10): 2039-47. PMID 8888719.
  2. topic/stomachPPI.html topic/stomachPPI