Difference between revisions of "Progressive transformation of germinal centers"

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==References==
==References==
{{Reflist|1}}
{{Reflist|1}}
==Additional reading==
*{{cite journal |author=Hansmann ML, Fellbaum C, Hui PK, Moubayed P |title=Progressive transformation of germinal centers with and without association to Hodgkin's disease |journal=Am. J. Clin. Pathol. |volume=93 |issue=2 |pages=219–26 |year=1990 |month=February |pmid=2405631 |doi= |url=}}
*{{cite journal |author=Kojima M, Nakamura S, Motoori T, ''et al.'' |title=Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients |journal=Int. J. Surg. Pathol. |volume=11 |issue=2 |pages=101–7 |year=2003 |month=April |pmid=12754626 |doi= |url=}}


[[Category:Lymph node pathology]]
[[Category:Lymph node pathology]]

Revision as of 10:38, 20 July 2011

Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.

General

  • Benign.
  • Classically in younger patients.
  • Associated with nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.[1]

Clinical:

  • Asymptomatic lymphadenopathy.

Microscopic

Features:

  • Follicular hyperplasia (many follicles).
  • Focally large germinal centers with:
    • Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
    • Expanded mantle zone.

Images:

See also

References

  1. 1.0 1.1 Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC (2002). "Progressive transformation of germinal centers. Report of 2 cases and review of the literature". Acta Haematol. 108 (1): 33–8. PMID 12145465.

Additional reading

  • Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
  • Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.