Post-transplant lymphoproliferative disorder
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Post-transplant lymphoproliferative disorder, abbreviated PTLD, is something afflicts people that had transplants (solid organ and bone marrow). It is essentially a type of B-cell lymphoma.
General
- Rare.
- B cell neoplasm associated with EBV.[1][2]
- May develop from a clinically latent EBV infection that is detectable by the presence of "passenger cells" = scattered EBER positive lymphocytes.[3]
- Commonly in the GI tract as it gets the most immunosuppression; immunosuppressives are taken orally -- not cleaned by the liver prior to reaching the GI tract.
Microscopic
Features:
- Similar to large cell lymphomas:
- Large lymphoid cells with a diameter ~2x a resting lymphocyte.
- Nucleoli.
DDx:
IHC
- B cell markers +ve.
- EBER diffusely +ve.
See also
- Diffuse large B cell lymphoma (DLBCL).
- Heart transplant pathology.
- Lung transplant pathology.
- Lymphoproliferative disorder.
References
- ↑ URL: http://emedicine.medscape.com/article/431364-overview. Accessed on: 10 February 2011.
- ↑ Gottschalk S, Rooney CM, Heslop HE (2005). "Post-transplant lymphoproliferative disorders". Annu. Rev. Med. 56: 29–44. doi:10.1146/annurev.med.56.082103.104727. PMID 15660500.
- ↑ URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422031/. Accessed on: 3 March 2011.