Poorly differentiated thyroid carcinoma

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Poorly differentiated thyroid carcinoma, abbreviated PDTC, is a distinct type of thyroid carcinoma that is recognized in the 2004 WHO classification of thyroid tumours.[1][2] It does not refer to high grade thyroid tumours.[1]



Required features - so called Turin criteria:[4]

  1. Solid, trabecular or insular pattern of growth.
  2. Absence of nuclear features for (conventional) papillary thyroid carcinoma.
  3. One of the following:
    1. Convoluted nuclei.
    2. >= 3 mitoses/10 HPF.
    3. Tumour necrosis.

See also


  1. 1.0 1.1 Tallini, G. (Dec 2011). "Poorly differentiated thyroid carcinoma. Are we there yet?". Endocr Pathol 22 (4): 190-4. doi:10.1007/s12022-011-9176-5. PMID 21969055.
  2. Volante, M.; Papotti, M. (Mar 2010). "Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours.". Endocr Pathol 21 (1): 1-6. doi:10.1007/s12022-009-9100-4. PMID 19960273.
  3. Asioli, S.; Erickson, LA.; Righi, A.; Jin, L.; Volante, M.; Jenkins, S.; Papotti, M.; Bussolati, G. et al. (Sep 2010). "Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression.". Mod Pathol 23 (9): 1269-78. doi:10.1038/modpathol.2010.117. PMID 20562850.
  4. Volante, M.; Collini, P.; Nikiforov, YE.; Sakamoto, A.; Kakudo, K.; Katoh, R.; Lloyd, RV.; LiVolsi, VA. et al. (Aug 2007). "Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach.". Am J Surg Pathol 31 (8): 1256-64. doi:10.1097/PAS.0b013e3180309e6a. PMID 17667551.