Difference between revisions of "Pneumocytoma"

From Libre Pathology
Jump to navigation Jump to search
(+SO)
Line 9: Line 9:
*Female in 40s.<ref name=pmid19415961>{{Cite journal  | last1 = Keylock | first1 = JB. | last2 = Galvin | first2 = JR. | last3 = Franks | first3 = TJ. | title = Sclerosing hemangioma of the lung. | journal = Arch Pathol Lab Med | volume = 133 | issue = 5 | pages = 820-5 | month = May | year = 2009 | doi =  | PMID = 19415961 }}</ref>
*Female in 40s.<ref name=pmid19415961>{{Cite journal  | last1 = Keylock | first1 = JB. | last2 = Galvin | first2 = JR. | last3 = Franks | first3 = TJ. | title = Sclerosing hemangioma of the lung. | journal = Arch Pathol Lab Med | volume = 133 | issue = 5 | pages = 820-5 | month = May | year = 2009 | doi =  | PMID = 19415961 }}</ref>
*Considered benign; excision is curative.
*Considered benign; excision is curative.
**Rare case reports of [[metastases]].
**Rare case reports of [[metastases]].<ref name=pmid27346414>{{Cite journal  | last1 = Pokharel | first1 = S. | last2 = Dhillon | first2 = SS. | last3 = Ylagan | first3 = L. | last4 = George | first4 = S. | last5 = Yendamuri | first5 = S. | title = Sclerosing Pneumocytoma with Lymph Node Metastasis. | journal = J Thorac Oncol | volume = 11 | issue = 10 | pages = 1802-4 | month = Oct | year = 2016 | doi = 10.1016/j.jtho.2016.06.005 | PMID = 27346414 }}</ref><ref name=pmid3009921>{{Cite journal  | last1 = Tanaka | first1 = I. | last2 = Inoue | first2 = M. | last3 = Matsui | first3 = Y. | last4 = Oritsu | first4 = S. | last5 = Akiyama | first5 = O. | last6 = Takemura | first6 = T. | last7 = Fujiwara | first7 = M. | last8 = Kodama | first8 = T. | last9 = Shimosato | first9 = Y. | title = A case of pneumocytoma (so-called sclerosing hemangioma) with lymph node metastasis. | journal = Jpn J Clin Oncol | volume = 16 | issue = 1 | pages = 77-86 | month = Mar | year = 1986 | doi =  | PMID = 3009921 }}</ref>


==Gross==
==Gross==

Revision as of 22:00, 17 February 2017

Pneumocytoma is a rare lung tumour that is typically benign. It is also known as benign sclerosing pneumocytoma.[1]

It was previously known as sclerosing hemangioma.

General

  • Derived from type 2 pneumocyte.[2]
  • Progesterone-receptor positive stromal cells.[3]

Epidemiology

  • Female in 40s.[4]
  • Considered benign; excision is curative.

Gross

  • Peripheral, solitary.
  • Well-circumscribed.

Microscopic

Features:[4]

  • Mixed cell population.
  • Variable architecture:
    • Papillary.
    • Sclerotic.
    • Solid.
    • Hemorrhagic.
  • +/-Granulomas.

DDx:[7]

IHC

Features:[8]

  • EMA +ve.
  • PR +ve.[3]
  • Ki-67 membranous pattern.[9]

Negative stains:[8]

  • SMA -ve.
  • CEA -ve.
  • CD34 -ve.
  • S100 -ve.
  • Chromogranin A -ve.

Others:[2]

  • TTF-1 +ve.
  • HNF-3 alpha +ve.
  • HNF-3 beta +ve.

Sign out

Lung, Left Lower Lobe, Core Biopsy:
     - Sclerosing pneumocytoma (sclerosing hemangioma).

Comment:
The lesion stains as follows:
POSITIVE: Ki-67 (membranous pattern), TTF-1, PR.
NEGATIVE: CD56, p53.

See also

References

  1. Chan, KW.; Gibbs, AR.; Lo, WS.; Newman, GR. (Jun 1982). "Benign sclerosing pneumocytoma of lung (sclerosing haemangioma).". Thorax 37 (6): 404-12. PMID 6291188.
  2. 2.0 2.1 Yamazaki, K. (Jul 2004). "Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins.". Virchows Arch 445 (1): 45-53. doi:10.1007/s00428-004-1023-3. PMID 15138814.
  3. 3.0 3.1 Einsfelder, BM.; Müller, KM. (Sep 2005). "["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung]". Pathologe 26 (5): 367-77. doi:10.1007/s00292-005-0751-8. PMID 15731902.
  4. 4.0 4.1 Keylock, JB.; Galvin, JR.; Franks, TJ. (May 2009). "Sclerosing hemangioma of the lung.". Arch Pathol Lab Med 133 (5): 820-5. PMID 19415961.
  5. Pokharel, S.; Dhillon, SS.; Ylagan, L.; George, S.; Yendamuri, S. (Oct 2016). "Sclerosing Pneumocytoma with Lymph Node Metastasis.". J Thorac Oncol 11 (10): 1802-4. doi:10.1016/j.jtho.2016.06.005. PMID 27346414.
  6. Tanaka, I.; Inoue, M.; Matsui, Y.; Oritsu, S.; Akiyama, O.; Takemura, T.; Fujiwara, M.; Kodama, T. et al. (Mar 1986). "A case of pneumocytoma (so-called sclerosing hemangioma) with lymph node metastasis.". Jpn J Clin Oncol 16 (1): 77-86. PMID 3009921.
  7. URL: http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf. Accessed on: 17 June 2010.
  8. 8.0 8.1 Rodriguez-Soto, J.; Colby, TV.; Rouse, RV. (Mar 2000). "A critical examination of the immunophenotype of pulmonary sclerosing hemangioma.". Am J Surg Pathol 24 (3): 442-50. PMID 10716159.
  9. Kim, BH.; Bae, YS.; Kim, SH.; Jeong, HJ.; Hong, SW.; Yoon, SO. (Feb 2013). "Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas.". APMIS 121 (2): 105-10. doi:10.1111/j.1600-0463.2012.02945.x. PMID 23030396.