Difference between revisions of "Paneth cell"

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[[Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | thumb | right |Paneth cell metaplasia. [[H&E stain]].]]
The '''Paneth cell''' is characteristic of the [[small intestine]]. It is also normal in the [[cecum]], ascending colon and transverse colon.
The '''Paneth cell''' is characteristic of the [[small intestine]]. It is also normal in the [[cecum]], ascending colon and transverse colon.



Revision as of 01:03, 19 January 2014

Paneth cell metaplasia. H&E stain.

The Paneth cell is characteristic of the small intestine. It is also normal in the cecum, ascending colon and transverse colon.

Paneth cell metaplasia redirect to this article.

General

  • Paneth cells should not be in the left colon[1] - if you see 'em think of IBD and other long-standing injurious processes.
  • Some claim that (friendly right colonic) paneth cells and paneth cell metaplasia look quite different and can be distinguished.[2]

Microscopic

Features:

  • Supranuclear eosinophilic granules.

DDx:

  • Enterochromaffin cells (AKA Kulchitsky cells).
    • Subnuclear eosinophilic granules.
  • Intraepithelial eosinophils.
    • Eosinophils have smaller (~1/2) more intensely red granules.

See also

References

  1. Tanaka M, Saito H, Kusumi T, et al (December 2001). "Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease". J. Gastroenterol. Hepatol. 16 (12): 1353–9. PMID 11851832. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353.
  2. Rubio CA, Nesi G (2003). "A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections". In Vivo 17 (1): 67–71. PMID 12655793.