Difference between revisions of "Ovarian small cell carcinoma of the hypercalcemic type"
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==IHC== | ==IHC== | ||
Features:<ref name=pmid17727473>{{Cite journal | last1 = Carlson | first1 = JW. | last2 = Nucci | first2 = MR. | last3 = Brodsky | first3 = J. | last4 = Crum | first4 = CP. | last5 = Hirsch | first5 = MS. | title = Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. | journal = Histopathology | volume = 51 | issue = 3 | pages = 305-12 | month = Sep | year = 2007 | doi = 10.1111/j.1365-2559.2007.02790.x | PMID = 17727473 }}</ref> | Features:<ref name=pmid17727473>{{Cite journal | last1 = Carlson | first1 = JW. | last2 = Nucci | first2 = MR. | last3 = Brodsky | first3 = J. | last4 = Crum | first4 = CP. | last5 = Hirsch | first5 = MS. | title = Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. | journal = Histopathology | volume = 51 | issue = 3 | pages = 305-12 | month = Sep | year = 2007 | doi = 10.1111/j.1365-2559.2007.02790.x | PMID = 17727473 }}</ref> | ||
*WT-1 +ve. | *[[WT-1]] +ve. | ||
*TTF-1 -ve. | *[[TTF-1]] -ve. | ||
*HPV -ve. | *HPV -ve. | ||
*p16 +ve/-ve. | *[[p16]] +ve/-ve. | ||
==See also== | ==See also== | ||
Revision as of 14:12, 6 June 2016
Ovarian small cell carcinoma of the hypercalcemic type, abbreviated OSSCHT, is a rare malignant ovarian tumour.
Small cell carcinoma, hypercalcemic type, and small cell carcinoma of the ovary, hypercalcemic type redirect here.
A proposed name of the entity is malignant rhabdoid tumour of the ovary, abbreviated MRTO.[1]
General
- Hypercalcemia.[2]
- Very rare.
- Most common undifferentiated ovarian malignancy in individuals less than 40 years old.[3]
- Associated with SMARCA4 mutations - may be familial.[3]
Microscopic
Features:[2]
- Small cell carcinoma.
- Follicle-like spaces.
DDx:
- Small cell carcinoma of the lung.
- Small cell carcinoma of the cervix.
- Sertoli-Leydig cell tumour.
- Juvenile granulosa cell tumour.
Images
www:
OSSCHT - low mag. (WC)
OSSCHT - intermed. mag. (WC)
OSSCHT - high mag. (WC)
OSSCHT - very high mag. (WC)
IHC
Features:[4]
See also
Miscellaneous ovarian tumours.
References
- ↑ Foulkes, WD.; Clarke, BA.; Hasselblatt, M.; Majewski, J.; Albrecht, S.; McCluggage, WG. (Jul 2014). "No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour.". J Pathol 233 (3): 209-14. doi:10.1002/path.4362. PMID 24752781.
- ↑ 2.0 2.1 Young, RH.; Oliva, E.; Scully, RE. (Nov 1994). "Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases.". Am J Surg Pathol 18 (11): 1102-16. PMID 7943531.
- ↑ 3.0 3.1 Witkowski L, Carrot-Zhang J, Albrecht S, et al. (May 2014). "Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type". Nat. Genet. 46 (5): 438–43. doi:10.1038/ng.2931. PMID 24658002.
- ↑ Carlson, JW.; Nucci, MR.; Brodsky, J.; Crum, CP.; Hirsch, MS. (Sep 2007). "Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis.". Histopathology 51 (3): 305-12. doi:10.1111/j.1365-2559.2007.02790.x. PMID 17727473.