Difference between revisions of "Ovarian microcystic stromal tumour"

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'''Ovarian microcystic stromal tumour''', abbreviated '''MST''', is a rare [[ovarian tumour]].
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'''Ovarian microcystic stromal tumour''' (abbreviated '''MST'''), also '''microcystic stromal tumour of the ovary''', is a rare [[ovarian tumour]].
  
 
==General==
 
==General==
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*Microcysts alternating with solid cellular regions.
 
*Microcysts alternating with solid cellular regions.
 
*Hyalinized fibrous stroma.
 
*Hyalinized fibrous stroma.
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===Images===
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<gallery>
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Image: Microcystic stromal tumour of ovary -- extremely low mag.jpg |MST - extremely low mag. (WC)
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Image: Microcystic stromal tumour of ovary -- very low mag.jpg |MST - very low mag. (WC)
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Image: Microcystic stromal tumour of ovary -- low mag.jpg |MST - low mag. (WC)
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Image: Microcystic stromal tumour of ovary -- intermed mag.jpg |MST - intermed. mag. (WC)
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Image: Microcystic stromal tumour of ovary -- high mag.jpg |MST - high mag. (WC)
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Image: Microcystic stromal tumour of ovary - alt -- high mag.jpg |MST - high mag. (WC)
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Image: Microcystic stromal tumour of ovary -- very high mag.jpg |MST - very high mag. (WC)
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</gallery>
  
 
==IHC==
 
==IHC==
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==Molecular==
 
==Molecular==
*CTNNB1 mutation.<ref name=pmid28551672>PMID: 28551672.</ref>
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*CTNNB1 mutation.<ref name=pmid28551672>{{Cite journal  | last1 = Na | first1 = K. | last2 = Kim | first2 = EK. | last3 = Jang | first3 = W. | last4 = Kim | first4 = HS. | title = CTNNB1 Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation. | journal = Anticancer Res | volume = 37 | issue = 6 | pages = 3249-3258 | month = Jun | year = 2017 | doi = 10.21873/anticanres.11688 | PMID = 28551672 }}</ref>
  
 
==References==
 
==References==

Latest revision as of 23:01, 10 June 2019

Ovarian microcystic stromal tumour (abbreviated MST), also microcystic stromal tumour of the ovary, is a rare ovarian tumour.

General

  • Evolving entity.
  • Reported in the testis.[1]

Microscopic

Features:[2]

  • Microcysts alternating with solid cellular regions.
  • Hyalinized fibrous stroma.

Images

IHC

Features:[2]

  • CD10 +ve (cytoplasmic).
  • Beta-catenin +ve (nuclear).
  • WT1 +ve.
  • Cyclin D1 +ve.
  • Inhibin -ve.
  • Calretinin -ve.
  • ER -ve.
  • PR -ve.

Molecular

  • CTNNB1 mutation.[3]

References

  1. Zhu, P.; Duan, Y.; Ao, Q.; Wang, G. (Oct 2018). "Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review.". Cancer Res Treat 50 (4): 1452-1457. doi:10.4143/crt.2017.414. PMID 29169232.
  2. 2.0 2.1 McCluggage, WG.; Chong, AS.; Attygalle, AD.; Clarke, BA.; Chapman, W.; Rivera, B.; Foulkes, WD. (Feb 2019). "Expanding the morphological spectrum of ovarian microcystic stromal tumour.". Histopathology 74 (3): 443-451. doi:10.1111/his.13755. PMID 30325056.
  3. Na, K.; Kim, EK.; Jang, W.; Kim, HS. (Jun 2017). "CTNNB1 Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation.". Anticancer Res 37 (6): 3249-3258. doi:10.21873/anticanres.11688. PMID 28551672.