Difference between revisions of "Nucleus-to-cytoplasm ratio"

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High NC ratio is strong predictor of malignancy.<ref name=pmid16556320>{{Cite journal  | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue =  | pages = 11 | month =  | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }}
High NC ratio is strong predictor of malignancy.<ref name=pmid16556320>{{Cite journal  | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue =  | pages = 11 | month =  | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }}
</ref>  Like very rule, there are exceptions:
</ref>  Like very rule, there are exceptions.


High NC ratio in normal cells:
===High NC ratio in normal cells===
*Lymphocytes.
*Lymphocytes.


Low NC ratio in cancer:
===Low NC ratio in cancer===
*[[Fibrolamellar hepatocellular carcinoma]].
*[[Fibrolamellar hepatocellular carcinoma]].
*[[Acinic cell carcinoma]].
*[[Acinic cell carcinoma]].
*Many others.


The classic malignant high NC ratio cell is:
===High NC ratio in cancer===
*[[Small cell carcinoma]].
The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the ''[[small round cell tumour]]'' group.
 
*Many other tumours.
Other malignant high NC ratio tumours are the [[small round cell tumour]]s.


==See also==
==See also==

Revision as of 23:36, 27 December 2011

Nucleus-to-cytoplasm ratio, also nuclear-cytoplasmic ratio, is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated NC ratio.

High NC ratio is strong predictor of malignancy.[1] Like very rule, there are exceptions.

High NC ratio in normal cells

  • Lymphocytes.

Low NC ratio in cancer

High NC ratio in cancer

The classic malignant high NC ratio cell is small cell carcinoma, which is in the small round cell tumour group.

  • Many other tumours.

See also

References

  1. Mehrotra, R.; Gupta, A.; Singh, M.; Ibrahim, R. (2006). "Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.". Mol Cancer 5: 11. doi:10.1186/1476-4598-5-11. PMID 16556320.