Difference between revisions of "Nodal nevus"

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{{ Infobox diagnosis
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| Name      = {{PAGENAME}}
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| Image      = Nodal nevus -- intermed mag.jpg
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| Width      =
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| Caption    =
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| Synonyms  = capsular nevus, benign nevus cells in lymph node
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| Micro      = bland nevus cells (lack prominent nucleoli, [[nuclear pleomorphism]], proliferative activity)
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| Subtypes  =
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| LMDDx      = [[malignant melanoma]]
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| Stains    =
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| IHC        = S-100 +ve
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| EM        =
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| Molecular  =
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| IF        =
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| Gross      = usually not apparent
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| Grossing  =
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| Staging    =
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| Site      = [[lymph node]]
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| Assdx      =
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| Syndromes  =
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| Clinicalhx =
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| Signs      = none
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| Symptoms  =
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| Prevalence = rare
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| Bloodwork  =
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| Rads      =
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| Endoscopy  =
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| Prognosis  = benign
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| Other      =
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| ClinDDx    = [[lymph node metastasis]]
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| Tx        = none
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}}
 
'''Nodal nevus''', also '''capsular nevus''', is benign [[lymph node]] findings that can be mistaken for [[malignant melanoma]].<ref name=pmid25081754>{{Cite journal  | last1 = Lee | first1 = JJ. | last2 = Granter | first2 = SR. | last3 = Laga | first3 = AC. | last4 = Saavedra | first4 = AP. | last5 = Zhan | first5 = Q. | last6 = Guo | first6 = W. | last7 = Xu | first7 = S. | last8 = Murphy | first8 = GF. | last9 = Lian | first9 = CG. | title = 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies. | journal = Mod Pathol | volume = 28 | issue = 2 | pages = 218-29 | month = Feb | year = 2015 | doi = 10.1038/modpathol.2014.99 | PMID = 25081754 }}</ref>
 
'''Nodal nevus''', also '''capsular nevus''', is benign [[lymph node]] findings that can be mistaken for [[malignant melanoma]].<ref name=pmid25081754>{{Cite journal  | last1 = Lee | first1 = JJ. | last2 = Granter | first2 = SR. | last3 = Laga | first3 = AC. | last4 = Saavedra | first4 = AP. | last5 = Zhan | first5 = Q. | last6 = Guo | first6 = W. | last7 = Xu | first7 = S. | last8 = Murphy | first8 = GF. | last9 = Lian | first9 = CG. | title = 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies. | journal = Mod Pathol | volume = 28 | issue = 2 | pages = 218-29 | month = Feb | year = 2015 | doi = 10.1038/modpathol.2014.99 | PMID = 25081754 }}</ref>
  
''Nevus in lymph node'' redirects here.
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'''Nevus in lymph node''' and '''benign nevus cells in lymph node''' redirect here.
  
 
==General==
 
==General==

Revision as of 23:51, 10 June 2019

Nodal nevus
Diagnosis in short

Synonyms capsular nevus, benign nevus cells in lymph node

LM bland nevus cells (lack prominent nucleoli, nuclear pleomorphism, proliferative activity)
LM DDx malignant melanoma
IHC S-100 +ve
Gross usually not apparent
Site lymph node

Signs none
Prevalence rare
Prognosis benign
Clin. DDx lymph node metastasis
Treatment none

Nodal nevus, also capsular nevus, is benign lymph node findings that can be mistaken for malignant melanoma.[1]

Nevus in lymph node and benign nevus cells in lymph node redirect here.

General

Gross

  • Usually not apparent.

Microscopic

Features:

  • Nevus cells with bland cytomorphology.
    • Lack size variation, nucleoli.
    • Non-proliferative.

Note:

  • No standardized criteria.[3]

DDx:

IHC

Features:[3]

  • S-100 +ve.

References

  1. Lee, JJ.; Granter, SR.; Laga, AC.; Saavedra, AP.; Zhan, Q.; Guo, W.; Xu, S.; Murphy, GF. et al. (Feb 2015). "5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies.". Mod Pathol 28 (2): 218-29. doi:10.1038/modpathol.2014.99. PMID 25081754.
  2. Prieto, VG. (09 2017). "Sentinel Lymph Nodes in Cutaneous Melanoma.". Clin Lab Med 37 (3): 417-430. doi:10.1016/j.cll.2017.05.002. PMID 28802493.
  3. 3.0 3.1 3.2 Davis, J.; Patil, J.; Aydin, N.; Mishra, A.; Misra, S. (2016). "Capsular nevus versus metastatic malignant melanoma - a diagnostic dilemma.". Int J Surg Case Rep 29: 20-24. doi:10.1016/j.ijscr.2016.10.040. PMID 27810606.