Neurothekeoma
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Neurothekeoma is a benign peripheral nerve sheath tumour.
It is also known as nerve sheath myxoma[1] and myxoma of the nerve sheath.
There is growing evidence that neurothekomas and dermal nerve sheath myxomas are distinct entities.[2]
General
- Rare.
- Female > male.
Microscopic
Features:[3]
- Superficial dermal lesion:
- Usu. lobulated or micronodular architecture - key feature.
- +/-Focal sheeting.
- Spindle/epithelioid morphology with pale eosinophilic cytoplasm - key feature.
- +/-Inflammation around lesion.
- +/-Surrounded by collagen.
- Usu. lobulated or micronodular architecture - key feature.
Notes:
- No atypia.
- Mitoses rare/none.
- Often poorly circumscribed.
Subtypes:[4]
- Cellular.
- Myxoid.
- Intermediate.
DDx:
- Dermatofibroma.
- Angiomatoid fibrous histiocytoma -- have cystic blood filled spaces, inflammation.[5]
Images
Neurothekeoma (WP)
www
IHC
Features:[3]
- NKI/C3 (AKA NKI-C3) +ve.
- NSE +/-ve.
Others:[6]
- Vimentin +ve.
- CD10 +ve.
- Microphthalmia transcription factor (MITF) +ve.
- PGP9.5 +ve.
- S100 +ve.[7]
- -ve in older literature.
See also
References
- ↑ Laskin, WB.; Fetsch, JF.; Miettinen, M. (Oct 2000). "The "neurothekeoma": immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics.". Hum Pathol 31 (10): 1230-41. doi:10.1053/hupa.2000.18474. PMID 11070116.
- ↑ Sheth, S.; Li, X.; Binder, S.; Dry, SM. (Mar 2011). "Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis.". Mod Pathol 24 (3): 343-54. doi:10.1038/modpathol.2010.203. PMID 21297585.
- ↑ 3.0 3.1 Hornick JL, Fletcher CD (March 2007). "Cellular neurothekeoma: detailed characterization in a series of 133 cases". Am. J. Surg. Pathol. 31 (3): 329–40. doi:10.1097/01.pas.0000213360.03133.89. PMID 17325474.
- ↑ Wang AR, May D, Bourne P, Scott G (November 1999). "PGP9.5: a marker for cellular neurothekeoma". Am. J. Surg. Pathol. 23 (11): 1401–7. PMID 10555009.
- ↑ URL: http://surgpathcriteria.stanford.edu/softfib/angiomatoid_fibrous_histiocytoma/. Accessed on: 11 May 2011.
- ↑ Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen M (July 2007). "Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information". Am. J. Surg. Pathol. 31 (7): 1103–14. doi:10.1097/PAS.0b013e31802d96af. PMID 17592278.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 541. ISBN 978-0443066542.