Necrobiosis lipoidica
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Necrobiosis lipoidica | |
---|---|
Diagnosis in short | |
Necrobiosis lipoidica. HPS stain. | |
| |
LM | (dermal) palisading granulomas around necrotic collagen; little mucin; no normal dermis between foci; plasma cells - common; +/-involvement of subcutis |
LM DDx | granuloma annulare, rheumatoid nodule |
Site | skin |
| |
Associated Dx | diabetes mellitus, rheumatoid arthritis |
Prevalence | uncommon |
Necrobiosis lipoidica is an uncommon granulomatous skin pathology.
General
Associated with:
- Diabetes mellitus - known as necrobiosis lipoidica diabeticorum.
- Rheumatoid arthritis.
Gross
Image:
Microscopic
Features:[1]
- Dermal palisading granuloma around:
- Necrotic collagen - key feature.
- Nuclei "missing" - have undergone karyolysis.
- Necrotic collagen - key feature.
- Little mucin, no normal dermis between foci.
- Plasma cells - common.[2]
- May involve adipose tissue.
DDx:
- Granuloma annulare - more mucin, normal dermis between foci,[1] plasma cells uncommon,[2] no fat involvement - usu. more superficial.
- Rheumatoid nodule.
Images
www:
- Necrobiosis lipoidica (dermatology.cdlib.org).
- Necrobiosis lipoidica (drmihm.com).
- Necrobiosis lipoidica (dermnetnz.org).
See also
References
- ↑ 1.0 1.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 51. ISBN 978-0443066542.
- ↑ 2.0 2.1 URL: http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html. Accessed on: 24 January 2012.