Multiple sclerosis
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Multiple sclerosis, abbreviated MS, is a chronic inflammatory condition of the central nervous system.
General
- A bread 'n butter disease of neurology in Canada.
Clinical:
- CSF: oligoclonal bands of immunoglobulin.[1]
Classification of MS lesions:
- Early active.
- Inactive.
- Early remyelinating.
- Late remyelinating.
Radiologic/Gross
Features:[2]
- White matter lesions.
- Cerebrum (classically): periventricular distribution.
- Optic nerves (optic neuritis) - classic presentation.
Microscopic
Features:[3]
- Perivascular inflammation.
- Esp. lymphocytes.
- Demyelination.
- Subcortical myelinated fibers are often spared.
Chronic lesions - specific features:[4]
- Macrophages.
- Astrocyte enlargement.
DDx:
Images
Demyelination in MS - CD68 stain. (WC/Marvin 101)
Demyelination in MS - KB stain. (WC/Marvin 101)
www:
- Multiple sclerosis masquerading as a diffuse astrocytoma - several images (upmc.edu).
- Tumefactive multiple sclerosis - several images (upmc.edu).
IHC
- HAM-56 - macrophages.
- CD8 - lymphocytes.
See also
References
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1311. ISBN 978-1416031215.
- ↑ URL: http://library.med.utah.edu/kw/ms/path.html. Accessed on: 12 July 2010.
- ↑ URL: http://library.med.utah.edu/kw/ms/path.html. Accessed on: 12 July 2010.
- ↑ Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 425 Q43. ISBN 978-1416025887.