Difference between revisions of "Multiple endocrine neoplasia"

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Memory device: '''3 Ps'''.
Memory device: '''3 Ps'''.


===MEN 2A/2B (II/III)===
===MEN 2A (II)===
* Parathyroid adenoma.
* Parathyroid adenoma.
* [[Medullary thyroid carcinoma]] (usu. preceded by C cell hyperplasia<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>).
* [[Medullary thyroid carcinoma]] (usu. preceded by C cell hyperplasia<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>).
* [[Pheochromocytoma]].  
* [[Pheochromocytoma]].  


Notes:
Notes - memory device:
*BOTH have parathyroid adenoma.
*Both MEN 1 and MEN 2A have parathyroid adenomas.
*EACH has one below and one above the diaphragm.
*Each has additional neoplasms below ''and'' above the diaphragm.
 
===MEN 3A (III)===
* Neuromas/[[ganglioneuroma]]s.
* [[Medullary thyroid carcinoma]] (usu. preceded by C cell hyperplasia<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>).
* [[Pheochromocytoma]].  


==Details==
==Details==

Revision as of 21:19, 19 March 2011

Multiple endocrine neoplasia, abbreviated MEN, refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

Simple

MEN 1

Memory device: 3 Ps.

MEN 2A (II)

Notes - memory device:

  • Both MEN 1 and MEN 2A have parathyroid adenomas.
  • Each has additional neoplasms below and above the diaphragm.

MEN 3A (III)

Details

MEN 1

Characteristics:[2]

  • Endocrine tumours usu. lead to most of the morbidity.
    • Usu. arise in the duodenum.
      • Zollinger-Ellison syndrome is common.

MEN 2A

Characteristics:[2]

  • Medullary thyroid carcinoma - in almost 100%.

Images:

Trivia:

MEN 2B

Characteristics:

References

  1. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2. Accessed on: 2 September 2010.
  2. 2.0 2.1 2.2 2.3 2.4 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1162. ISBN 978-1416031215. }}
  3. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1160. ISBN 978-1416031215. }}
  4. URL: http://www.ncbi.nlm.nih.gov/omim/162300. Accessed on: 19 November 2010.
  5. Haraguchi M, Kinoshita H, Koori M, et al. (2007). "Multiple rectal carcinoids with diffuse ganglioneuromatosis". World J Surg Oncol 5: 19. doi:10.1186/1477-7819-5-19. PMC 1805501. PMID 17306015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805501/.