Difference between revisions of "Multiple endocrine neoplasia"

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m (→‎MEN 2B: tweak)
(→‎MEN 1: wikify)
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*Endocrine tumours usu. lead to most of the morbidity.
*Endocrine tumours usu. lead to most of the morbidity.
**Usu. arise in the duodenum.
**Usu. arise in the duodenum.
***Zollinger-Ellison syndrome is common.
**May present as [[Zollinger-Ellison syndrome]].


===MEN 2A===
===MEN 2A===

Revision as of 16:41, 8 January 2012

Multiple endocrine neoplasia, abbreviated MEN, refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

Simple

MEN 1

Memory device: 3 Ps.

MEN 2A (II)

Notes - memory device:

  • Both MEN 1 and MEN 2A have parathyroid adenomas.
  • Each has additional neoplasms below and above the diaphragm.

MEN 2B (III)

Details

MEN 1

Characteristics:[2]

MEN 2A

Characteristics:[2]

  • Medullary thyroid carcinoma - in almost 100%.

Treatment:

  • Patients are advised to have prophylactic thyroidectomy.

Images:

Trivia:

MEN 2B

Characteristics:

Treatment:

  • Patients are advised to have prophylactic thyroidectomy.

References

  1. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2. Accessed on: 2 September 2010.
  2. 2.0 2.1 2.2 2.3 2.4 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1162. ISBN 978-1416031215. }}
  3. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1160. ISBN 978-1416031215. }}
  4. Online 'Mendelian Inheritance in Man' (OMIM) 162300
  5. Haraguchi M, Kinoshita H, Koori M, et al. (2007). "Multiple rectal carcinoids with diffuse ganglioneuromatosis". World J Surg Oncol 5: 19. doi:10.1186/1477-7819-5-19. PMC 1805501. PMID 17306015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805501/.
  6. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 215. ISBN 978-0443066573.