Multifocal fibrosing thyroiditis
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Multifocal fibrosing thyroiditis, abbreviated MFT, is a benign pathology of the thyroid that can mimic papillary thyroid carcinoma.
It is also known as multifocal sclerosing thyroiditis.[1]
General
- Uncommon - though may be under-recognized.
- Female predominant in largest series (93% of cases versus 7% of cases).[1]
Microscopic
Features:[1]
- Fibrotic foci - two foci required - key feature.
- May be: (1) sharply demarcated from the surround parenchyma (stellate or triangular) or (2) band-like.
Note:
- MFT on average has 16 foci of fibrosis. These foci range in size from approximately 0.35 to 15 mm.[1]
- Should not have have nuclear pseudoinclusions or psammoma bodies.[1]
DDx:[1]
- Hashimoto thyroiditis.
- Adenomatoid hyperplasia of thyroid.
- Papillary thyroid carcinoma.
- Riedel thyroiditis.
- Changes due to fine needle aspiration - should have hemosiderin, not multifocal.