Metanephric adenoma
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
| Metanephric adenoma | |
|---|---|
| Diagnosis in short | |
 Metanephric adenoma. H&E stain. | |
|
| |
| LM | small uniform cells with fine chromatin, no apparent nucleolus, and a relatively smooth nuclear membrane; variable architecture - may be sheets, ductal or micropapillary, +/-psammoma bodies |
| LM DDx | Wilms tumour, papillary renal cell carcinoma (type 1), renal mucinous tubular and spindle cell carcinoma |
| IHC | WT-1 +ve, CD57 +ve, AMACR -ve, CD56 -ve |
| Site | kidney - see kidney tumours |
|
| |
| Clinical history | usu. adults, occasionally children |
| Prevalence | uncommon |
| Prognosis | good, benign |
Metanephric adenoma is a benign tumour of the kidney.
It should not be confused mesonephric adenoma, another term for nephrogenic adenoma.
This can be remembered as follows: metanephric adenoma is a tumour.
General
- Benign.
- Afflicts adults and occasionally children.
- May be associated with polycythemia.[1]
Gross
- Sharply circumscribed.
- Not encapsulated.[2]
Microscopic
Features:[3]
- Small uniform cells with:
- Fine chromatin.
- No apparent nucleolus.
- A relatively smooth nuclear membrane.
- Variable architecture - may be sheets, ductal or micropapillary.
- +/-Psammoma bodies.
DDx:
- Epithelioid nephroblastoma (Wilms tumour) - these typically have:
- Irregular nuclear membrane.
- Nucleoli.
- Mitoses (rare in metanephric adenoma).
- Papillary RCC.[3]
- Renal mucinous tubular and spindle cell carcinoma.
- Other small round cell tumours, e.g. small cell carcinoma.
Images
Metanephric adenoma - PaRCC-like - low mag. (WC/Nephron)
Metanephric adenoma - PaRCC-like - intermed. mag. (WC/Nephron)
Metanephric adenoma - PaRCC-like - very high mag. (WC/Nephron)
Metanephric adenoma - PaRCC-like - very high mag. (WC/Nephron)
www:
IHC
- WT-1 +ve.[4]
- CD57 +ve.[4]
- AMACR -ve.[4]
- CD56 -ve.[5]
- Positive in Wilms tumour[5] and small cell carcinoma.
- CK7 +ve (focal).[5]
- TTF-1 -ve.[citation needed]
Sign out
Left Kidney, Total Nephrectomy: - Metanephric adenoma, see comment. COMMENT: The tumour stains as follows: POSITIVE: WT1, CD57, PAX8. NEGATIVE: CD56, TTF-1, AMACR.
See also
References
- ↑ Le Nué, R.; Marcellin, L.; Ripepi, M.; Henry, C.; Kretz, JM.; Geiss, S. (Aug 2011). "Conservative treatment of metanephric adenoma. A case report and review of the literature.". J Pediatr Urol 7 (4): 399-403. doi:10.1016/j.jpurol.2010.09.010. PMID 21220212.
- ↑ Mantoan Padilha, M.; Billis, A.; Allende, D.; Zhou, M.; Magi-Galluzzi, C. (May 2013). "Metanephric adenoma and solid variant of papillary renal cell carcinoma: common and distinctive features.". Histopathology 62 (6): 941-53. doi:10.1111/his.12106. PMID 23551615.
- ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 284. ISBN 978-0781765275.
- ↑ 4.0 4.1 4.2 Watanabe, S.; Naganuma, H.; Shimizu, M.; Ota, S.; Murata, S.; Nihei, N.; Matsushima, J.; Mikami, S. et al. (2013). "Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases.". Case Rep Pathol 2013: 675875. doi:10.1155/2013/675875. PMID 24083046.
- ↑ 5.0 5.1 5.2 Muir, TE.; Cheville, JC.; Lager, DJ. (Oct 2001). "Metanephric adenoma, nephrogenic rests, and Wilms' tumor: a histologic and immunophenotypic comparison.". Am J Surg Pathol 25 (10): 1290-6. PMID 11688464.
.