Medullary colorectal carcinoma

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Medullary colorectal carcinoma is a rare type of colorectal carcinoma.


  • Rare subtype of colorectal carcinoma.
  • Typically has Microsatellite instability.[1]
  • Prognostic significance dependent on study.
    • A small series suggests the prognosis of medullary carcinoma with MSI is worse that conventional colorectal carcinoma without MSI.[2]
    • A series with 102 cases suggests a better prognosis when compared on the basis of other pathological characteristics.[3]


  • Well-circumscribed.



  • Poorly differentiated carcinoma:
    • Noninfiltrative border.
    • Solid pattern/nests.
    • No gland formation.
    • Lymphocytic infiltrate.




  • CDX2 +ve.
  • Beta-catenin +ve.
  • MLH1 loss of staining.


  • CDX2, beta-catenin, MLH1 useful for differentiating from poorly differentiated colorectal carcinoma.

See also


  1. 1.0 1.1 "Medullary carcinoma of the colon: a case series and review of the literature". In Vivo 28 (3): 311–4. 2014. PMID 24815832.
  2. "Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability". Prz Gastroenterol 12 (3): 208–214. 2017. doi:10.5114/pg.2016.64740. PMC 5672702. PMID 29123583. //
  3. "Medullary colorectal carcinoma revisited: a clinical and pathological study of 102 cases". Ann. Surg. Oncol. 22 (9): 2988–96. September 2015. doi:10.1245/s10434-014-4355-5. PMID 25572685.