Medial calcific sclerosis

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Medial calcific sclerosis is a type of arteriosclerosis that has no significant clinical impact.

Medial calcific sclerosis
Diagnosis in short

Medial calcific sclerosis. H&E stain.

Synonyms Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis)

LM calcifications of the tunica media
LM DDx atherosclerosis
Site blood vessels - arteries

Prognosis good
Treatment (nothing)

It is also known as Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, and Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis).

General

  • Usually of no clinical consequence.

Microscopic

Features:[1]

  • Medial calcification (purple irregular stuff on H&E -- calcium phosphate).

Note:

  • Lumen unaffected.

DDx:

  • Atherosclerosis (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.

Images

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RIGHT LEG, BELOW KNEE AMPUTATION:
- MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT.
- MEDIAL CALCIFIC SCLEROSIS.
- SKIN WITH DERMAL FIBROSIS.

COMMENT:
The sections may not be representative of disease in the distal vascular bed.

See also

References

  1. Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 7. ISBN 978-1416002741.