Mast cell

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Mast cells in mastocytosis. H&E stain.

The mast cell is an uncommonly cell that occasionally causes problems.

Microscopic

Features:

Ovoid/round cell with moderate amount of gray granular cytoplasm.
Nuclear ovoid/round.
- No obvious nucleolus.
May be more abundant around blood vessels.

Notes:

Lymphocyte vs. mast cell:
- Lymphocytes = round; mast cells = ovoid.

Images

www:

Mastocytosis - high mag. (WC)
Mastocytosis - very high mag. (WC)

Diseases

Mastocytosis.
- Urticaria pigmentosa.
Asthma.^[1]

Conditions associated with the presence of mast cells

Stains

Giemsa stain.
Tyrosinase.^[4] (???)

IHC

CD117 +ve.^[5]
CD34 +ve.^[6]^{[citation needed]}

References

↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 370-2. ISBN 978-1416054542.
↑ Carr, NJ.; Warren, AY. (Jan 1993). "Mast cell numbers in melanocytic naevi and cutaneous neurofibromas.". J Clin Pathol 46 (1): 86-7. PMID 8432898.
↑ Williamson, SR.; Eble, JN.; Amin, MB.; Gupta, NS.; Smith, SC.; Sholl, LM.; Montironi, R.; Hirsch, MS. et al. (Jul 2014). "Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.". Mod Pathol. doi:10.1038/modpathol.2014.86. PMID 25034258.
↑ URL: http://www.nature.com/jid/journal/v53/n1/full/jid1969105a.html. Accessed on: 20 December 2011.
↑ Schmetzer, O.; Valentin, P.; Smorodchenko, A.; Domenis, R.; Gri, G.; Siebenhaar, F.; Metz, M.; Maurer, M. (Jul 2014). "A novel method to generate and culture human mast cells: Peripheral CD34+ stem cell-derived mast cells (PSCMCs).". J Immunol Methods. doi:10.1016/j.jim.2014.07.003. PMID 25038510.
↑ Duşe, AO.; Ceauşu, RA.; Mezei, T.; Cîmpean, AM.; Gaje, P.; Ioniţă, H.; Jung, I. (2011). "Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density.". Rom J Morphol Embryol 52 (3 Suppl): 1091-6. PMID 22119830.

[Ref_PCPBoD8_370-2-1] Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 370-2. ISBN 978-1416054542.

[pmid8432898-2] Carr, NJ.; Warren, AY. (Jan 1993). "Mast cell numbers in melanocytic naevi and cutaneous neurofibromas.". J Clin Pathol 46 (1): 86-7. PMID 8432898.

[pmid25034258-3] Williamson, SR.; Eble, JN.; Amin, MB.; Gupta, NS.; Smith, SC.; Sholl, LM.; Montironi, R.; Hirsch, MS. et al. (Jul 2014). "Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.". Mod Pathol. doi:10.1038/modpathol.2014.86. PMID 25034258.

[4] URL: http://www.nature.com/jid/journal/v53/n1/full/jid1969105a.html. Accessed on: 20 December 2011.

[pmid25038510-5] Schmetzer, O.; Valentin, P.; Smorodchenko, A.; Domenis, R.; Gri, G.; Siebenhaar, F.; Metz, M.; Maurer, M. (Jul 2014). "A novel method to generate and culture human mast cells: Peripheral CD34+ stem cell-derived mast cells (PSCMCs).". J Immunol Methods. doi:10.1016/j.jim.2014.07.003. PMID 25038510.

[pmid22119830-6] Duşe, AO.; Ceauşu, RA.; Mezei, T.; Cîmpean, AM.; Gaje, P.; Ioniţă, H.; Jung, I. (2011). "Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density.". Rom J Morphol Embryol 52 (3 Suppl): 1091-6. PMID 22119830.

[1]

[2]

[3]

[4]

[5]

[6]