Difference between revisions of "Lung carcinoma with ALK rearrangement"
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*[[Adenocarcinoma of the lung]]. | *[[Adenocarcinoma of the lung]]. | ||
*[[Signet ring cell carcinoma]]. (?) | |||
*[[Mucinous carcinoma]]. (?) | |||
==IHC== | ==IHC== | ||
Revision as of 11:20, 26 December 2013
Lung carcinoma with ALK rearrangement is subset of lung adenocarcinoma.
General
Microscopic
Features:[1]
- Adenocarcinoma - at least focally.
- Solid signet-ring cell pattern - common.
- Mucinous cribriform pattern - common.
DDx:
IHC
Features:[1]
- p63 +ve.
- TTF-1 +ve.
Molecular
- EML4-ALK fusion -- inv(2)(p21p23).[3]
See also
References
- ↑ 1.0 1.1 1.2 Yoshida, A.; Tsuta, K.; Nakamura, H.; Kohno, T.; Takahashi, F.; Asamura, H.; Sekine, I.; Fukayama, M. et al. (Aug 2011). "Comprehensive histologic analysis of ALK-rearranged lung carcinomas.". Am J Surg Pathol 35 (8): 1226-34. doi:10.1097/PAS.0b013e3182233e06. PMID 21753699.
- ↑ Crystal, AS.; Shaw, AT. (Mar 2011). "New targets in advanced NSCLC: EML4-ALK.". Clin Adv Hematol Oncol 9 (3): 207-14. PMID 21475126.
- ↑ Li, Y.; Ye, X.; Liu, J.; Zha, J.; Pei, L. (Jan 2011). "Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors.". Neoplasia 13 (1): 1-11. PMID 21245935.