Difference between revisions of "Low-grade oncocytic renal tumour"

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'''Renal oncocytic tumour that is CD117 negative and CK7 positive''', also known as '''low grade oncocytic renal tumour''', is an unusual [[renal tumour]] that does not neatly fit into any WHO renal neoplasia category.
'''Low-grade oncocytic renal tumour''', is an unusual [[renal tumour]] that does not neatly fit into any WHO renal neoplasia category.  It is also known as '''renal oncocytic tumour that is CD117 negative and CK7 positive'''.  


Whether it is a distinct entity is not clear as of 2019.<ref name=pmid30895640/>
Whether it is a distinct entity is not clear as of 2019.<ref name=pmid30895640/>

Revision as of 02:58, 7 April 2021

Low-grade oncocytic renal tumour, is an unusual renal tumour that does not neatly fit into any WHO renal neoplasia category. It is also known as renal oncocytic tumour that is CD117 negative and CK7 positive.

Whether it is a distinct entity is not clear as of 2019.[1]

General

  • Very rare.
  • Benign behaviour based on a small series.[1]

Microscopic

Features:[2]

  • Oncocytic cytoplasm.
  • Round nuclei.
  • Tubular or solid architecture.
  • Edematous areas with loosly arranged cells.
  • Low ISUP nucleolar grade - grade 1 or 2.

DDx:

Images

  • LGORT - low mag. (WC)

  • LGORT - intermed. mag. (WC)

  • LGORT - intermed. mag. (WC)

  • LGORT - high mag. (WC)

  • LGORT - high mag. (WC)

  • LGORT - high mag. (WC)

IHC

Features:

  • CK7 +ve.
  • CD117 -ve.

Others:

  • CD10 -ve/+ve.
  • AMACR -ve/+ve.
  • CA9 -ve.
  • CK20 -ve.
  • CD10 -ve.

See also

References

  1. ↑ 1.0 1.1 Trpkov K, Williamson SR, Gao Y, Martinek P, Cheng L, Sangoi AR, Yilmaz A, Wang C, San Miguel Fraile P, Perez Montiel DM, Bulimbasić S, Rogala J, Hes O (August 2019). "Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive): a distinct entity?". Histopathology 75 (2): 174–184. doi:10.1111/his.13865. PMID 30895640.
  2. ↑ Trpkov K, Williamson S, Martinek P, Cheng L, San Miguel Fraile P, Yilmaz A, Hes O, Oncocytic Renal Tumors with CD117 Negative, Cytokeratin 7 Positive Immunoprofile are Different from Eosinophilic Chromophobe Renal Cell Carcinoma (ChrRCC) and Oncocytoma. United States and Canadian Academy of Pathology Annual Meeting 2018.
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