Difference between revisions of "Lipofuscin"

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'''Lipofuscin''' is benign pigment that can be confused for melanin. It is also known as ''age pigment'', as it as associated strongly with aging.<ref name=pmid11976186>{{cite journal |vauthors=Porta EA |title=Pigments in aging: an overview |journal=Ann. N. Y. Acad. Sci. |volume=959 |issue= |pages=57–65 |date=April 2002 |pmid=11976186 |doi=10.1111/j.1749-6632.2002.tb02083.x |url=}}</ref>
[[Image:Melanosis coli intermed mag.jpg|thumb|right|[[Micrograph]] showing lipofuscin in the colon; this is known as ''[[pseudomelanosis coli]]''. [[H&E stain]].]]
[[Image:Stromal lipofuscinosis of the seminal vesicle - alt -- high mag.jpg |right|thumb|[[Micrograph]] showing stromal lipofuscinosis. [[H&E stain]].]]'''Lipofuscin''' is benign pigment that can be confused for melanin. It is also known as ''age pigment'', as it as associated strongly with aging.<ref name=pmid11976186>{{cite journal |authors=Porta EA |title=Pigments in aging: an overview |journal=Ann. N. Y. Acad. Sci. |volume=959 |issue= |pages=57–65 |date=April 2002 |pmid=11976186 |doi=10.1111/j.1749-6632.2002.tb02083.x |url=}}</ref>


==Called "melanosis" when it is really lipofuscin==
==Called "melanosis" when it is really lipofuscin==
*Bladder lipofuscin pigmentation.<ref name=pmid31148387>{{cite journal |vauthors=Atieh M, McIntire PJ, Kilic I, Picken MM, Flanigan RC, Barkan GA, Pambuccian SE |title=Lipofuscin pigmentation (so called "melanosis") of the bladder |journal=Diagn. Cytopathol. |volume=47 |issue=9 |pages=968–971 |date=September 2019 |pmid=31148387 |doi=10.1002/dc.24204 |url=}}</ref>
*Bladder lipofuscin pigmentation.<ref name=pmid31148387>{{cite journal |authors=Atieh M, McIntire PJ, Kilic I, Picken MM, Flanigan RC, Barkan GA, Pambuccian SE |title=Lipofuscin pigmentation (so called "melanosis") of the bladder |journal=Diagn. Cytopathol. |volume=47 |issue=9 |pages=968–971 |date=September 2019 |pmid=31148387 |doi=10.1002/dc.24204 |url=}}</ref>
*[[Pseudomelanosis coli]] also known as "melanosis coli".<ref name=pmid18666316>{{cite journal |author=Freeman HJ |title="Melanosis" in the small and large intestine |journal=World J. Gastroenterol. |volume=14 |issue=27 |pages=4296-9 |year=2008 |month=July |pmid=18666316 |doi= |url=http://www.wjgnet.com/1007-9327/14/4296.asp}}</ref>
*[[Pseudomelanosis coli]] also known as "melanosis coli".<ref name=pmid18666316>{{cite journal |author=Freeman HJ |title="Melanosis" in the small and large intestine |journal=World J. Gastroenterol. |volume=14 |issue=27 |pages=4296-9 |year=2008 |month=July |pmid=18666316 |doi= |url=http://www.wjgnet.com/1007-9327/14/4296.asp}}</ref>


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*Iron.
*Iron.
*Bile.
*Bile.
*Exogenous pigment.


==Stains==
==Stains==
Features:
Features:
*PAS +ve.<ref name=pmid11976186>{{cite journal |vauthors=Porta EA |title=Pigments in aging: an overview |journal=Ann. N. Y. Acad. Sci. |volume=959 |issue= |pages=57–65 |date=April 2002 |pmid=11976186 |doi=10.1111/j.1749-6632.2002.tb02083.x |url=}}</ref>
*[[PAS stain]] +ve.<ref name=pmid11976186>{{cite journal |authors=Porta EA |title=Pigments in aging: an overview |journal=Ann. N. Y. Acad. Sci. |volume=959 |issue= |pages=57–65 |date=April 2002 |pmid=11976186 |doi=10.1111/j.1749-6632.2002.tb02083.x |url=}}</ref>
*Melanin -ve.
*[[Melanin stain]] -ve.


==See also==
==See also==

Latest revision as of 20:23, 24 May 2020

Micrograph showing lipofuscin in the colon; this is known as pseudomelanosis coli. H&E stain.
Micrograph showing stromal lipofuscinosis. H&E stain.

Lipofuscin is benign pigment that can be confused for melanin. It is also known as age pigment, as it as associated strongly with aging.[1]

Called "melanosis" when it is really lipofuscin

Microscopic

Features:

  • Brown pigment.

DDx:

  • Melanin.
  • Iron.
  • Bile.
  • Exogenous pigment.

Stains

Features:

See also

References

  1. 1.0 1.1 Porta EA (April 2002). "Pigments in aging: an overview". Ann. N. Y. Acad. Sci. 959: 57–65. doi:10.1111/j.1749-6632.2002.tb02083.x. PMID 11976186.
  2. Atieh M, McIntire PJ, Kilic I, Picken MM, Flanigan RC, Barkan GA, Pambuccian SE (September 2019). "Lipofuscin pigmentation (so called "melanosis") of the bladder". Diagn. Cytopathol. 47 (9): 968–971. doi:10.1002/dc.24204. PMID 31148387.
  3. Freeman HJ (July 2008). ""Melanosis" in the small and large intestine". World J. Gastroenterol. 14 (27): 4296-9. PMID 18666316. http://www.wjgnet.com/1007-9327/14/4296.asp.