Laryngeal carcinoma

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Laryngeal carcinoma is a subset of head and neck pathology.

Normal histology

The normal histology is dependent on the site.[1]

Pathology

Laryngeal squamous cell carcinoma

General

  • 95% of laryngeal carcinomas.[2]

Risk factors:[2]

  1. Smoking.
  2. Alcohol.

Note:

  • Asbestos exposure is also reported to be associated.[3]

Carinoma - subclassification by site

It is generally divided the following way:[4]

 
 
 
 
 
 
 
 
Laryngeal cancer
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Supraglottis
 
 
Glottis
 
 
Subglottis

Features:[5][6]

  • Prevalence - glottis > supraglottis > subglottis.
  • Glottic carcinoma tends to present earlier (as it affects phonation) and, therefore, has a better prognosis.

Microscopic

See squamous cell carcinoma.

Sign out

LEFT FALSE VOCAL CORD, BIOPSY:
- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, NONKERATINIZING,
  WITH LYMPHOVASCULAR INVASION.

COMMENT:
The presence of invasive squamous cell carcinoma is confirmed by a second pathologist.

See also

References

  1. Koren, R.; Kristt, D.; Shvero, J.; Yaniv, E.; Dekel, Y.; Gal, R. (2002). "The spectrum of laryngeal neoplasia: the pathologist's view.". Pathol Res Pract 198 (11): 709-15. PMID 12530572.
  2. 2.0 2.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 396. ISBN 978-1416054542.
  3. Offermans, NS.; Vermeulen, R.; Burdorf, A.; Goldbohm, RA.; Kauppinen, T.; Kromhout, H.; van den Brandt, PA. (Jan 2014). "Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study.". J Occup Environ Med 56 (1): 6-19. doi:10.1097/JOM.0000000000000060. PMID 24351898.
  4. URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf. Accessed on: 2 May 2012.
  5. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 24. ISBN 978-0781765275.
  6. URL: http://www.health.am/cr/more/statistics-and-prognosis-for-cancer-of-the-larynx/. Accessed on: 2 May 2012.