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Keratoconus is a pathology of the cornea characterized by thinning and bulging.[1]


  • Relatively common.



  • Thinning of the cornea.[2]
  • Anterior limiting lamina with variable thickness.[2]


  • Anterior limiting lamina = layer below the basement membrane.[3]
    • Normally has a uniform thickenss.


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Left Corneal Button, Excision:
- Consistent with keratoconus.
- NEGATIVE for dysplasia.


The sections show a cornea with thinning and an irregular anterior limiting lamina.

See also


  1. Arnalich-Montiel, F.; Alió Del Barrio, JL.; Alió, JL. (2016). "Corneal surgery in keratoconus: which type, which technique, which outcomes?". Eye Vis (Lond) 3: 2. doi:10.1186/s40662-016-0033-y. PMID 26783544.
  2. 2.0 2.1 2.2 Mathew, JH.; Goosey, JD.; Bergmanson, JP. (Aug 2011). "Quantified histopathology of the keratoconic cornea.". Optom Vis Sci 88 (8): 988-97. doi:10.1097/OPX.0b013e31821ffbd4. PMID 21623252.
  3. Mathew, JH.; Bergmanson, JP.; Doughty, MJ. (Sep 2008). "Fine structure of the interface between the anterior limiting lamina and the anterior stromal fibrils of the human cornea.". Invest Ophthalmol Vis Sci 49 (9): 3914-8. doi:10.1167/iovs.07-0707. PMID 18765633.