Intravascular large B-cell lymphoma
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Intravascular large B-cell lymphoma | |
---|---|
Diagnosis in short | |
Intravascular lymphoma. H&E stain. | |
| |
LM | abundant atypical intravascular lymphoid cells (large ~2-3X size of a mature lymphocyte, nucleolus prominent) |
LM DDx | T-cell intravascular lymphoma |
IHC | CD20 +ve, CD34 -ve, CD3 -ve |
Site | blood vessels |
| |
Signs | non-specific presentation - may include fever, skin lesions |
Prevalence | rare |
Prognosis | poor |
Clin. DDx | dependent on presentation, may include stroke |
Intravascular large B-cell lymphoma refers to a rare form of lymphoma that is intravascular, B-cell derived, and does not manifest as a mass.
Several terms have been use to refer this entity, including angiotropic lymphoma, intravascular malignant lymphomatosis and malignant angioendotheliomatosis.
General
- Rare - est. at one in million.[1]
Clinical:
- Often a non-specific presentation.[2]
- +/-Fever.
- +/-Multiple infarcts.
- +/-Non-specific skin lesions.
Microscopic
Features:
- Abundant atypical intravascular lymphoid cells that are:
- Large (~2-3X size of a mature lymphocyte or RBC).
- Nucleolus prominent.
Notes:
- It may be hard to find RBCs in the vessels.
- Looks sorta like a DLBCL -- but is intravascular.
Images
www:
- ILBCL (ascopubs.org).[2]
- ILBCL in bone marrow (alphamedpress.org).
- ILBCL - various images (oxfordjournals.org).
- ILBCL (upmc.edu).[3]
- ILBCL - several images (upmc.edu).
IHC
Features:[2]
- CD20 +ve - key feature.
- CD79a +ve.[1]
- CD3 -ve.
- CD34 -ve.
See also
References
- ↑ 1.0 1.1 Raza, M.; Qayyum, S.; Raza, S.; Goorha, S. (May 2012). "Intravascular B-cell lymphoma: an elusive diagnosis.". J Clin Oncol 30 (15): e144-5. doi:10.1200/JCO.2011.38.7720. PMID 22529262.
- ↑ 2.0 2.1 2.2 Lapkuviene O, Forchetti D, Roepke JE (October 2001). "Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms". J. Clin. Oncol. 19 (19): 3988–91. PMID 11579120. http://jco.ascopubs.org/content/19/19/3988.full.
- ↑ URL: http://path.upmc.edu/cases/case473.html. Accessed on: 21 January 2012.