Intraepithelial lymphocytes
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Intraepithelial lymphocytes, abbreviated IELs, is the presence of lymphocytes between (benign) epithelial cells. IELs are seen in a number of contexts.
Lymphocytic proctitis. H&E stain.
The epithelial cells in the context of IEL are presumed to be benign. Lymphocytes infiltrating between malignant (epithelial) cells is dealt with in the tumour infiltrating lymphocytes article.
Small bowel
- Celiac disease - classic cause.
- Giardia.
- Helicobacter gastritis.
- Crohn's disease.[citation needed]
- Morbid obesity.[1]
Large Bowel
- Lymphocytic colitis.[2]
- Collagenous colitis.[2]
- Celiac disease.[3]
- Crohn's disease.[4]
- Drug-induced colitis.[citation needed]
See also
References
- ↑ Harpaz, N.; Levi, GS.; Yurovitsky, A.; Kini, S. (Mar 2007). "Intraepithelial lymphocytosis in architecturally normal small intestinal mucosa: association with morbid obesity.". Arch Pathol Lab Med 131 (3): 344; author reply 344. doi:10.1043/1543-2165(2007)131[344b:IR]2.0.CO;2. PMID 17516730.
- ↑ 2.0 2.1 Najarian, RM.; Hait, EJ.; Leichtner, AM.; Glickman, JN.; Antonioli, DA.; Goldsmith, JD. (Jan 2009). "Clinical significance of colonic intraepithelial lymphocytosis in a pediatric population.". Mod Pathol 22 (1): 13-20. doi:10.1038/modpathol.2008.139. PMID 19116628.
- ↑ Fine, KD.; Lee, EL.; Meyer, RL. (Dec 1998). "Colonic histopathology in untreated celiac sprue or refractory sprue: is it lymphocytic colitis or colonic lymphocytosis?". Hum Pathol 29 (12): 1433-40. PMID 9865829.
- ↑ Goldstein, NS.; Gyorfi, T. (Sep 1999). "Focal lymphocytic colitis and collagenous colitis: patterns of Crohn's colitis?". Am J Surg Pathol 23 (9): 1075-81. PMID 10478667.