Difference between revisions of "Intestinal metaplasia of the gallbladder"

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It is also known as '''gallbladder [[intestinal metaplasia]]'''.
It is also known as '''gallbladder [[intestinal metaplasia]]'''.
==General==
==General==
*Associated with [[chronic cholecystitis]].<ref name=pmid11702256>{{Cite journal  | last1 = Sai | first1 = K. | last2 = Kajiwara | first2 = H. | title = An immunohistochemical study of metaplastic endocrine cells in human gallbladder cancer. | journal = J Hepatobiliary Pancreat Surg | volume = 8 | issue = 5 | pages = 453-60 | month =  | year = 2001 | doi =  | PMID = 11702256 }}
</ref>
**Not associated with [[acute cholecystitis]].
Significance:
Significance:
*Increased risk of carcinoma.<ref name=pmid8364865>{{Cite journal  | last1 = Duarte | first1 = I. | last2 = Llanos | first2 = O. | last3 = Domke | first3 = H. | last4 = Harz | first4 = C. | last5 = Valdivieso | first5 = V. | title = Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution, and probability of detection in routine histologic samples. | journal = Cancer | volume = 72 | issue = 6 | pages = 1878-84 | month = Sep | year = 1993 | doi =  | PMID = 8364865 }}</ref>
*Increased risk of carcinoma.<ref name=pmid8364865>{{Cite journal  | last1 = Duarte | first1 = I. | last2 = Llanos | first2 = O. | last3 = Domke | first3 = H. | last4 = Harz | first4 = C. | last5 = Valdivieso | first5 = V. | title = Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution, and probability of detection in routine histologic samples. | journal = Cancer | volume = 72 | issue = 6 | pages = 1878-84 | month = Sep | year = 1993 | doi =  | PMID = 8364865 }}</ref>
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www:
www:
*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-129-3-386-f01&doi=10.1043%2F1543-2165%282005%29129%3C386%3APPOGDA%3E2.0.CO%3B2 IM - among other things (archivesofpathology.org)].<ref name=pmid15737036>{{Cite journal  | last1 = Mukhopadhyay | first1 = S. | last2 = Landas | first2 = SK. | title = Putative precursors of gallbladder dysplasia: a review of 400 routinely resected specimens. | journal = Arch Pathol Lab Med | volume = 129 | issue = 3 | pages = 386-90 | month = Mar | year = 2005 | doi = 10.1043/1543-2165(2005)129386:PPOGDA2.0.CO;2 | PMID = 15737036 }}</ref>
*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-129-3-386-f01&doi=10.1043%2F1543-2165%282005%29129%3C386%3APPOGDA%3E2.0.CO%3B2 IM - among other things (archivesofpathology.org)].<ref name=pmid15737036>{{Cite journal  | last1 = Mukhopadhyay | first1 = S. | last2 = Landas | first2 = SK. | title = Putative precursors of gallbladder dysplasia: a review of 400 routinely resected specimens. | journal = Arch Pathol Lab Med | volume = 129 | issue = 3 | pages = 386-90 | month = Mar | year = 2005 | doi = 10.1043/1543-2165(2005)129386:PPOGDA2.0.CO;2 | PMID = 15737036 }}</ref>
==Stains==
*Alcian blue/PAS +ve.


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Revision as of 02:14, 15 December 2013

Intestinal metaplasia of the gallbladder
Diagnosis in short

Gallbladder with intestinal metaplasia. H&E stain.
LM DDx gallbladder mucosa with goblet cells
Stains Alcian blue stain +ve
Site gallbladder
Associated Dx chronic cholecystitis
Prognosis benign, increased risk of carcinoma

Intestinal metaplasia of the gallbladder is a pathology of the gallbladder associated with an increased risk of gallbladder carcinoma.

It is also known as gallbladder intestinal metaplasia.

General

Significance:

  • Increased risk of carcinoma.[2]

Gross

  • No specific changes.

Microscopic

Features:[3]

Note:

  • Often accompanied by antral type metplasia.
    • Gastric antral-type epithelium - may form glands.

DDx:

Images

  • GB with IM - low mag.

  • GB with IM - intermed. mag.

  • GB with IM - high mag.

www:

Stains

  • Alcian blue/PAS +ve.

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GALLBLADDER, CHOLECYSTECTOMY: 
- INTESTINAL METAPLASIA OF THE GALLBLADDER, FOCAL. 
- CHRONIC CHOLECYSTITIS. 
- CHOLELITHIASIS.
- NEGATIVE FOR DYSPLASIA.

See also

References

  1. ↑ Sai, K.; Kajiwara, H. (2001). "An immunohistochemical study of metaplastic endocrine cells in human gallbladder cancer.". J Hepatobiliary Pancreat Surg 8 (5): 453-60. PMID 11702256.
  2. ↑ Duarte, I.; Llanos, O.; Domke, H.; Harz, C.; Valdivieso, V. (Sep 1993). "Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution, and probability of detection in routine histologic samples.". Cancer 72 (6): 1878-84. PMID 8364865.
  3. ↑ Albores-Saavedra, J.; Nadji, M.; Henson, DE.; Ziegels-Weissman, J.; Mones, JM. (Jun 1986). "Intestinal metaplasia of the gallbladder: a morphologic and immunocytochemical study.". Hum Pathol 17 (6): 614-20. PMID 2872152.
  4. ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 1789. ISBN 978-0781740517.
  5. ↑ Mukhopadhyay, S.; Landas, SK. (Mar 2005). "Putative precursors of gallbladder dysplasia: a review of 400 routinely resected specimens.". Arch Pathol Lab Med 129 (3): 386-90. doi:10.1043/1543-2165(2005)129386:PPOGDA2.0.CO;2. PMID 15737036.
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