Inflammatory fibroid polyp

From Libre Pathology
Jump to navigation Jump to search

Inflammatory fibroid polyp, abbreviated IFP, is an uncommon gastrointestinal polyp.

Inflammatory fibroid polyp
Diagnosis in short

Inflammatory fibroid polyp. H&E stain.
LM proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils (usually prominent), +/-leiomyoma/schwannoma-like areas - with nuclear palisading
LM DDx inflammatory myofibroblastic tumour, GIST, hemangiopericytoma, eosinophilic gastritis, schwannoma
IHC CD34 +ve, vimentin +ve, CD117 -ve, S-100 -ve
Molecular +/-PDGFRA mutations
Site stomach, other places in the GI tract
Prevalence uncommon
Prognosis good - benign

General

  • Benign.
  • Through-out GI tract.
  • Can be thought of as granulation tissue-like.[1]
  • Uncommon.

Microscopic

Features:[2]

  • Proliferating spindle cells (fibroid) - key feature.
    • Loosely arranged, concentrically, around blood vessels.[3]
    • Perivascular hypocellular zones.[1]
  • Inflammation:
    • Eosinophils - often prominent.
  • +/-Leiomyoma/schwannoma-like areas - with nuclear palisading.[1]
  • +/-Vascular for fibrous tissue.
  • Poorly circumscribed/infiltrates into the lamina propria.
  • +/-Myxoid stroma.[4]

Notes:

  • Concentric = share the same centre.[5]

DDx:[6]

Images

  • Low mag.

  • Intermed. mag.

  • High mag.

  • High mag.

  • Very high mag.

IHC

Features:[2]

  • CD34 +ve.
    • There is a CD34 -ve variant.
  • Vimentin +ve -- diffuse.[7]

Others:

  • CD117 -ve.[8]
  • S100 -ve.
  • Cyclin D1 +ve.[9]

Molecular

  • A subset have mutations in PDGFRA.[2]

See also

References

  1. ↑ 1.0 1.1 1.2 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 138. ISBN 978-0470519035.
  2. ↑ 2.0 2.1 2.2 Daum, O.; Hatlova, J.; Mandys, V.; Grossmann, P.; Mukensnabl, P.; Benes, Z.; Michal, M. (May 2010). "Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors).". Virchows Arch 456 (5): 491-7. doi:10.1007/s00428-010-0914-8. PMID 20393746.
  3. ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 115. ISBN 978-0443066573.
  4. ↑ Islam, RS.; Patel, NC.; Lam-Himlin, D.; Nguyen, CC. (Oct 2013). "Gastric polyps: a review of clinical, endoscopic, and histopathologic features and management decisions.". Gastroenterol Hepatol (N Y) 9 (10): 640-51. PMID 24764778.
  5. ↑ URL: http://dictionary.reference.com/browse/concentric. Accessed on: 29 November 2011.
  6. ↑ Rossi, P.; Montuori, M.; Balassone, V.; Ricciardi, E.; Anemona, L.; Manzelli, A.; Petrella, G.. "Inflammatory fibroid polyp. A case report and review of the literature.". Ann Ital Chir 83 (4): 347-51. PMID 22759473.
  7. ↑ Kolodziejczyk, P.; Yao, T.; Tsuneyoshi, M. (Nov 1993). "Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases.". Am J Surg Pathol 17 (11): 1159-68. PMID 8214261.
  8. ↑ Ozolek, JA.; Sasatomi, E.; Swalsky, PA.; Rao, U.; Krasinskas, A.; Finkelstein, SD. (Mar 2004). "Inflammatory fibroid polyps of the gastrointestinal tract: clinical, pathologic, and molecular characteristics.". Appl Immunohistochem Mol Morphol 12 (1): 59-66. PMID 15163021.
  9. ↑ Pantanowitz, L.; Antonioli, DA.; Pinkus, GS.; Shahsafaei, A.; Odze, RD. (Jan 2004). "Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin.". Am J Surg Pathol 28 (1): 107-14. PMID 14707872.
Retrieved from "https://librepathology.org/w/index.php?title=Inflammatory_fibroid_polyp&oldid=41524"