Hypersensitivity
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Hypersensitivity is an inappropriate immune system response. It is a thingy one may get quizzed on.
Gell & Coombs classification
Gell & Coombs, in the 1960s, came-up with a classification that has endured.
Type (I-IV) | Formal name[1] | Name | Example | Mediator | Pathology |
---|---|---|---|---|---|
I | Immediate h. | Allergic h. | anaphylaxis, (atopic) bronchial asthma, allergies | antibodies (IgE) | mast cells, inflammation (esp. eosinophils), edema |
II | Antibody mediated h. | Cytotoxic antibody dependent h. | Goodpasture syndrome,[2] Graves disease | antibodies (IgG, IgM) | (antibody-mediated) phagocytosis & lysis |
III | Immune complex mediated h. | Immune complex mediated h. | systemic lupus erythematosus, hypersensitivity pneumonitis,[3] rheumatoid arthritis | antigen-antibody complex | inflammation, vasculitis with fibrinoid necrosis |
IV | Cell-mediated h. | Delayed-type hypersensitivity | tuberculosis, contact dermatitis, chronic transplant rejection, inflammatory bowel disease | activated T cells | perivascular inflammation, granulomas |
Memory device ACID:[4]
- Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
- ↑ Briggs, WA.; Johnson, JP.; Teichman, S.; Yeager, HC.; Wilson, CB. (Sep 1979). "Antiglomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture's syndrome.". Medicine (Baltimore) 58 (5): 348-61. PMID 384140.
- ↑ Kaltreider, HB. (Nov 1993). "Hypersensitivity pneumonitis.". West J Med 159 (5): 570-8. PMID 8279154. http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8279154/?tool=pubmed.
- ↑ URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.