Hypersensitivity

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Hypersensitivity is a thingy one may get quized on.

Gell & Goombs classification

Type (I-IV) Formal name[1] Name Example Mediator Pathology
I Immediate h. Allergic h. anaphylaxis, (atopic) bronchial asthma, allergies antibodies (IgE) mast cells, inflammation (esp. eosinophils), edema
II Antibody mediated h. Cytotoxic antibody dependent h. Goodpasture syndrome, Graves disease antibodies (IgG, IgM) (antibody-mediated) phagocytosis & lysis
III Immune complex mediated h. Immune complex mediated h. systemic lupus erythematosus, hypersensitivity pneumonititis, rheumatoid arthritis antigen-antibody complex inflammation, vasculitis with fibrinoid necrosis
IV Cell-mediated h. Delayed-type hypersensitivity tuberculosis, contact dermatitis, chronic transplant rejection activated T cells perivascular inflammation, granulomas


Memory device ACID:[2]

  • Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.

See also

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
  2. URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.