Difference between revisions of "Hypersensitivity"
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| '''Cell-mediated h.''' | | '''Cell-mediated h.''' | ||
| Delayed-type hypersensitivity | | Delayed-type hypersensitivity | ||
| [[tuberculosis]], [[contact dermatitis]], chronic transplant rejection | | [[tuberculosis]], [[contact dermatitis]], chronic transplant rejection, [[inflammatory bowel disease]] | ||
| activated T cells | | activated T cells | ||
| perivascular inflammation, [[granuloma]]s | | perivascular inflammation, [[granuloma]]s | ||
Revision as of 19:41, 13 November 2011
Hypersensitivity is a thingy one may get quized on.
Gell & Goombs classification
| Type (I-IV) | Formal name[1] | Name | Example | Mediator | Pathology |
|---|---|---|---|---|---|
| I | Immediate h. | Allergic h. | anaphylaxis, (atopic) bronchial asthma, allergies | antibodies (IgE) | mast cells, inflammation (esp. eosinophils), edema |
| II | Antibody mediated h. | Cytotoxic antibody dependent h. | Goodpasture syndrome, Graves disease | antibodies (IgG, IgM) | (antibody-mediated) phagocytosis & lysis |
| III | Immune complex mediated h. | Immune complex mediated h. | systemic lupus erythematosus, hypersensitivity pneumonitis,[2] rheumatoid arthritis | antigen-antibody complex | inflammation, vasculitis with fibrinoid necrosis |
| IV | Cell-mediated h. | Delayed-type hypersensitivity | tuberculosis, contact dermatitis, chronic transplant rejection, inflammatory bowel disease | activated T cells | perivascular inflammation, granulomas |
Memory device ACID:[3]
- Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
- ↑ Kaltreider, HB. (Nov 1993). "Hypersensitivity pneumonitis.". West J Med 159 (5): 570-8. PMID 8279154. http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8279154/?tool=pubmed.
- ↑ URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.